Krasnick J, Patterson R, Roberts M
Division of Allergy-Immunology, Northwestern Memorial Hospital, Chicago, Illinois, USA.
Ann Allergy Asthma Immunol. 1995 Sep;75(3):239-41.
Allergic asthma, allergic bronchopulmonary aspergillosis, and hypersensitivity pneumonitis are all forms of immunologically mediated lung disease. Recognition that more than one of these diseases may co-exist is necessary for proper patient management.
To report a case of extrinsic (cat) asthma, allergic bronchopulmonary aspergillosis, hypersensitivity pneumonitis, and potentially fatal asthma. Immunologic mechanisms and treatment of these diseases are discussed.
The study is a case report from a university hospital setting. Serum precipitating antibodies against avian antigens were measured using gel-diffusion technique. Serum IgE levels were measured and skin testing was performed to selected antigens.
The patient had positive cutaneous reactivity to cat antigen and Aspergillus. Serology for allergic bronchopulmonary aspergillosis and serum precipitating antibodies to finch extract were positive. Symptoms improved and prednisone requirements decreased after removal of finches.
A case of cat asthma, potentially fatal asthma, allergic bronchopulmonary aspergillosis, and hypersensitivity pneumonitis is presented. Early recognition and treatment of multifactorial immunologic lung disease with avoidance measures and use of corticosteroids can prevent progressive respiratory damage.
过敏性哮喘、变应性支气管肺曲霉病和过敏性肺炎均为免疫介导的肺部疾病形式。认识到这些疾病中的不止一种可能同时存在对于患者的正确管理很有必要。
报告一例伴有变应性支气管肺曲霉病、过敏性肺炎及潜在致命性哮喘的外源性（猫）哮喘病例。讨论这些疾病的免疫机制及治疗方法。
本研究是一份来自大学医院的病例报告。采用凝胶扩散技术检测血清中针对禽类抗原的沉淀抗体。检测血清IgE水平，并对选定抗原进行皮肤试验。
该患者对猫抗原和曲霉皮肤反应呈阳性。变应性支气管肺曲霉病血清学检查及针对雀类提取物的血清沉淀抗体呈阳性。移除雀类后症状改善，泼尼松需求量减少。
本文报告了一例猫哮喘、潜在致命性哮喘、变应性支气管肺曲霉病和过敏性肺炎病例。早期识别并采用避免措施及使用皮质类固醇治疗多因素免疫性肺部疾病可预防进行性呼吸损害。
