Khan A S, Spiropoulou C F, Morzunov S, Zaki S R, Kohn M A, Nawas S R, McFarland L, Nichol S T
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta GA 30333, USA.
J Med Virol. 1995 Jul;46(3):281-6. doi: 10.1002/jmv.1890460320.
A fatal case of hantaviral illness occurred in Louisiana, outside of the range of P. maniculatus, the rodent reservoir for Sin Nombre virus. Hantavirus RNA and antigens were detected in patient autopsy tissues, and nucleotide sequence analysis of amplified polymerase chain reaction (PCR) products identified a newly recognized unique hantavirus, provisionally named Bayou virus. Prominent features of the clinical illness are compatible with hantavirus pulmonary syndrome (HPS), but several features such as renal insufficiency and intraalveolar hemorrhage are more compatible with hemorrhagic fever with renal syndrome (HFRS), a disease associated with Eurasian hantaviruses.
一例汉坦病毒病致死病例发生在路易斯安那州，该地不在白足鼠（Sin Nombre病毒的啮齿类宿主）分布范围内。在患者尸检组织中检测到汉坦病毒RNA和抗原，对扩增的聚合酶链反应（PCR）产物进行核苷酸序列分析，鉴定出一种新发现的独特汉坦病毒，暂命名为河口病毒。该临床疾病的显著特征与汉坦病毒肺综合征（HPS）相符，但肾功能不全和肺泡内出血等一些特征更符合肾综合征出血热（HFRS），一种与欧亚汉坦病毒相关的疾病。
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