硬皮病中异常的皮肤胶原蛋白。
Abnormal skin collagen in scleroderma.
作者信息
Blumenkrantz N, Asboe-Hansen G
出版信息
Acta Derm Venereol. 1978;58(1):75-93.
PMID:75639
Abstract
A significant decrease in the content of hydroxyproline and hydroxylysine was found in the skin of patients with generalized scleroderma (acrosclerosis), the lowering of Hyp being more marked than that of Hyl. The production of an abnormal collagen or a change from one collagen type to another is suggested to take place.
摘要
在全身性硬皮病（肢端硬化症）患者的皮肤中，发现羟脯氨酸和羟赖氨酸含量显著降低，其中羟脯氨酸含量的降低比羟赖氨酸更为明显。提示可能发生了异常胶原蛋白的产生或胶原蛋白类型的转变。
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