Ammitzbøll T, Serup J
Acta Derm Venereol. 1984;64(6):534-7.
Hydroxyproline (Hyp), hydroxylysine (Hyl), and proline (Pro) were assayed in the urine from 28 patients with localized scleroderma (13 with localized morphoea plaques, 13 with generalized morphoea, and two with scleroderma en coup de sabre), as well as 17 control persons. The levels of Hyp, Hyl and Pro were elevated in patients with localized morphoea plaques as compared to the controls indicating major changes of the collagen metabolism in this type of localized scleroderma.
对28例局限性硬皮病患者（13例局限性硬斑病斑块型、13例泛发性硬斑病、2例剑伤性硬皮病）以及17名对照者的尿液进行了羟脯氨酸（Hyp）、羟赖氨酸（Hyl）和脯氨酸（Pro）检测。与对照组相比，局限性硬斑病斑块型患者的Hyp、Hyl和Pro水平升高，表明这类局限性硬皮病中胶原代谢发生了重大变化。
