Blumenkrantz N, Asboe-Hanson G
Acta Derm Venereol. 1978;58(4):359-61.
In sclerodermal skin, the values for proline (Pro), hydroxyproline (Hyp) and hydroxylsine (Hyl) are lower than in normal skin. The molar ratio Hyp to Hyl is lowered. The molar ratio Pro to Hyp was found to be elevated, while that of Pro to Hyl was like that of normal skin. It was concluded that in slceroderma the hydroxylation of Pro to Hyp is incomplete, resulting in an abnormal collagen.
在硬皮病皮肤中,脯氨酸(Pro)、羟脯氨酸(Hyp)和羟赖氨酸(Hyl)的值低于正常皮肤。Hyp与Hyl的摩尔比降低。发现Pro与Hyp的摩尔比升高,而Pro与Hyl的摩尔比与正常皮肤相似。得出的结论是,在硬皮病中,Pro向Hyp的羟基化不完全,导致胶原蛋白异常。