代谢通量的生理控制：多位点调节的必要性。
Physiological control of metabolic flux: the requirement for multisite modulation.
作者信息
Fell D A, Thomas S
机构信息
School of Biological Sciences, Oxford Brookes University, Headington, U.K.
出版信息
Biochem J. 1995 Oct 1;311 ( Pt 1)(Pt 1):35-9. doi: 10.1042/bj3110035.
Abstract
Biochemists have long assumed that the flux through a metabolic pathway can be controlled by the activity of a key regulatory enzyme near the beginning of the pathway. We present the accumulating evidence that every step in this assumption is flawed. Instead, effective physiological control of metabolism is shown to involve simultaneous multisite modulation through action on a number of enzymes.
摘要
长期以来，生物化学家们一直认为，代谢途径的通量可以由该途径起始附近关键调节酶的活性来控制。我们提出越来越多的证据表明，这一假设中的每一步都是有缺陷的。相反，代谢的有效生理控制显示涉及通过作用于多种酶的同时多位点调节。
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