Periquet B A, Jammes N M, Lambert W E, Tricoire J, Moussa M M, Garcia J, Ghisolfi J, Thouvenot J
Purpan Hospital, Toulouse, France.
AIDS. 1995 Aug;9(8):887-93. doi: 10.1097/00002030-199508000-00009.
Micronutrients (zinc, copper, selenium, vitamin A, E, and carotenoids) are essential for the integrity of host defences. This study was designed to determine the prevalence of abnormalities of the micronutrient levels in HIV-1-seropositive children.
Prospective study.
The study was performed on HIV-1-infected children at the Paediatric Haematology and Oncology Unit of Toulouse Hospital, France.
Twenty-one children, suffering from HIV-1 infection and 21 control subjects of similar age (2-9 years) were included in the study. In the HIV-1-infected children, two subgroups were considered according to stage (non-AIDS or AIDS), based on the Centers for Disease Control and Prevention 1987 criteria.
The first statistically significant deficiencies occurred at non-AIDS stage and were confirmed at AIDS stage: P < 0.05 for lycopene, retinol, tocopherol and P < 0.001 for transthyretin and serum albumin. Levels of copper (40%) and long-chain polyunsaturated fatty acids (21%) were higher in the non-AIDS group than the controls.
Biological impairing of the micronutrient levels was observed in the non-AIDS stage without clinical sign. This information is useful in delineating eventual and well considered nutritional intervention strategies that may improve the clinical status of HIV-1-infected children and perhaps alter the course of their disease.
微量营养素（锌、铜、硒、维生素A、E和类胡萝卜素）对宿主防御的完整性至关重要。本研究旨在确定HIV-1血清阳性儿童微量营养素水平异常的患病率。
前瞻性研究。
该研究在法国图卢兹医院儿科血液学和肿瘤学部对HIV-1感染儿童进行。
21名感染HIV-1的儿童和21名年龄相仿（2至9岁）的对照受试者纳入研究。在感染HIV-1的儿童中，根据疾病控制和预防中心1987年的标准，按阶段（非艾滋病或艾滋病）分为两个亚组。
首次具有统计学意义的缺乏出现在非艾滋病阶段，并在艾滋病阶段得到证实：番茄红素、视黄醇、生育酚P<0.05，转甲状腺素蛋白和血清白蛋白P<0.001。非艾滋病组铜（40%）和长链多不饱和脂肪酸（21%）水平高于对照组。
在非艾滋病阶段观察到微量营养素水平的生物学损害，但无临床症状。该信息有助于制定最终且经过充分考虑的营养干预策略，可能改善HIV-1感染儿童的临床状况，并可能改变其疾病进程。
