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卡介苗对在对半抗原载体复合物早期反应期间细胞免疫和体液免疫的影响。

The effects of BCG on both cellular and humoral immunity during the early response to a hapten carrier complex.

作者信息

Neveu P J

出版信息

Clin Exp Immunol. 1976 Oct;26(1):169-72.

PMID:63343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540825/
Abstract

Cell-mediated reactions to the carrier and antibody-mediated reactions to hapten and carrier were studied in guinea-pigs treated with a single i.v. injection of BCG at different intervals of time before immunization with two different doses of a hapten-carrier complex. The results clearly show that BCG-induced delayed hypersensitivity reactions to the carrier and decreased antibody synthesis to the hapten. It is proposed that BCG acts on a dispatcher cell which controls both cellular and humoral immunity.

摘要

在用两种不同剂量的半抗原-载体复合物免疫前的不同时间间隔，对豚鼠进行单次静脉注射卡介苗处理，研究了对载体的细胞介导反应以及对半抗原和载体的抗体介导反应。结果清楚地表明，卡介苗诱导了对载体的迟发型超敏反应，并降低了对半抗原的抗体合成。有人提出，卡介苗作用于一个控制细胞免疫和体液免疫的调度细胞。

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The effects of BCG on both cellular and humoral immunity during the early response to a hapten carrier complex.卡介苗对在对半抗原载体复合物早期反应期间细胞免疫和体液免疫的影响。
Clin Exp Immunol. 1976 Oct;26(1):169-72.
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引用本文的文献

1
The effects of thiol moiety of levamisole on both cellular and humoral immunity during the early response to a hapten-carrier complex.左旋咪唑硫醇部分在对半抗原-载体复合物早期反应期间对细胞免疫和体液免疫的影响。
Clin Exp Immunol. 1978 Jun;32(3):419-22.
2
Stimulation and inhibition of macrophages prior to immunization with a hapten-carrier conjugate.在用半抗原-载体偶联物免疫之前对巨噬细胞进行刺激和抑制。
Immunology. 1977 Aug;33(2):269-73.

本文引用的文献

1
PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.纯化抗2,4-二硝基苯基抗体的制备
Methods Med Res. 1964;10:94-102.
2
Studies on hypersensitivity. I. Delayed and Arthustype skin reactivity to protein conjugates in guinea pigs.超敏反应研究。I. 豚鼠对蛋白质结合物的迟发型和阿瑟斯型皮肤反应性
Immunology. 1959 Jan;2(1):53-63.
3
Relationships between antibodies and experimental allergic encephalomyelitis. V. Antibodies and delayed hypersensitivity in production and prevention of experimental allergic encephalomyelitis.抗体与实验性变应性脑脊髓炎的关系。V. 抗体与实验性变应性脑脊髓炎产生及预防中的迟发型超敏反应
Int Arch Allergy Appl Immunol. 1970;38(4):403-12. doi: 10.1159/000230292.
4
Specific fractionation of immunocompetent cells.免疫活性细胞的特异性分级分离
Transplant Rev. 1970;5:76-104. doi: 10.1111/j.1600-065x.1970.tb00357.x.
5
Enhancement of renal allografts in rats and man.大鼠和人类同种异体肾移植的增强
Transplant Rev. 1972;13:115-41. doi: 10.1111/j.1600-065x.1972.tb00062.x.
6
Modulation of the immune response of guinea pigs by repeated BCG scarification.重复卡介苗划痕接种对豚鼠免疫反应的调节作用。
Proc Soc Exp Biol Med. 1974 Nov;147(2):344-9. doi: 10.3181/00379727-147-38338.
7
Separation of T effector cells in humoral and cellular immunity.体液免疫和细胞免疫中T效应细胞的分离。
Nature. 1974 Dec 13;252(5484):607-8. doi: 10.1038/252607a0.
8
Immunopotentiation with BCG. II. Modulation of the response to sheep red blood cells.卡介苗免疫增强作用。II. 对绵羊红细胞反应的调节
J Natl Cancer Inst. 1973 Nov;51(5):1669-76. doi: 10.1093/jnci/51.5.1669.
9
Cell-mediated immunity and serum blocking factors in patients with chronic dermatophytic infections.慢性皮肤癣菌感染患者的细胞介导免疫和血清阻断因子
Int Arch Allergy Appl Immunol. 1974;46(6):849-57. doi: 10.1159/000231187.
10
Dissociation of T cell helper function and delayed hypersensitivity.T细胞辅助功能与迟发型超敏反应的分离
J Immunol. 1974 Dec;113(6):1872-5.