Neveu P J
Immunology. 1976 Aug;31(2):257-62.
The different components of the immune response to hapten-carrier conjugates have been supposed to interact with each other. In order to elucidate the interrelationship between hapten and carrier moieties of the antigen molecule at the cellular level, the homologous carrier alone or the hapten conjugated to an heterologous carrier were injected before immunization with the hapten-carrier conjugate. Delayed hypersensitivity to the carrier could be depressed by pretreatment with the hapten or with the carrier depending on which time interval was chosen to elapse between the two injections. The results could be explained by antigenic competition, occurring at the cellular level, between hapten and carrier moieties of the antigen molecule.
对半抗原-载体缀合物免疫反应的不同组成部分被认为会相互作用。为了在细胞水平阐明抗原分子的半抗原和载体部分之间的相互关系，在对半抗原-载体缀合物进行免疫接种之前，单独注射同源载体或与异源载体偶联的半抗原。取决于两次注射之间选择的时间间隔，对载体的迟发型超敏反应可通过用半抗原或载体进行预处理而受到抑制。这些结果可以用抗原分子的半抗原和载体部分在细胞水平发生的抗原竞争来解释。
