Neveu P J
Clin Exp Immunol. 1978 Jun;32(3):419-22.
Cell-mediated reactions to the carrier and antibody-mediated reactions to the hapten were studied in guinea-pigs treated with a single i.v. injection of the thiol moiety of levamisole (DTC), before or after immunization with a hapten-carrier complex. The results show that a heavy dose of DTC induced delayed hypersensitivity reactions to the carrier and decreased antibody synthesis to the hapten. On the other hand, with a small dose of DTC no delayed hypersensitivity could be induced, but antibody synthesis to the hapten was depressed or enhanced, depending upon whether the injection was done before or after immunization. The mechanisms whereby DTC modulated the immune response are discussed.
在用半抗原-载体复合物免疫豚鼠之前或之后，通过静脉内单次注射左旋咪唑的硫醇部分（二硫代氨基甲酸盐，DTC），研究了对载体的细胞介导反应和对半抗原的抗体介导反应。结果表明，大剂量的DTC诱导了对载体的迟发型超敏反应，并降低了对半抗原的抗体合成。另一方面，小剂量的DTC不会诱导迟发型超敏反应，但根据注射是在免疫之前还是之后进行，对半抗原的抗体合成会受到抑制或增强。文中讨论了DTC调节免疫反应的机制。
