杆状病毒与昆虫细胞基因表达：杆状病毒生物技术综述
Baculovirus and insect cell gene expression: review of baculovirus biotechnology.
作者信息
Patterson R M, Selkirk J K, Merrick B A
机构信息
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
出版信息
Environ Health Perspect. 1995 Jul-Aug;103(7-8):756-9. doi: 10.1289/ehp.95103756.
The BEVS continues to evolve as a powerful, flexible tool for molecular biology, protein function, and biomedical research. Future developments offer the promise of replacement of hazardous chemical insecticides with environmentally safe biopesticides, construction of baculovirus vectors which encode genes for specific post-translational modifications, and establishment of efficient, stably transformed insect cell lines. FDA approval of BEVS-produced products offer the prospect of new biopharmaceuticals, in particular human therapeutics and vaccines, to improve human health and increase the quality of life for millions of people.
杆状病毒表达载体系统（BEVS）作为分子生物学、蛋白质功能和生物医学研究的一种强大而灵活的工具，仍在不断发展。未来的发展有望用环境安全的生物杀虫剂取代有害化学杀虫剂，构建编码特定翻译后修饰基因的杆状病毒载体，并建立高效、稳定转化的昆虫细胞系。美国食品药品监督管理局（FDA）对杆状病毒表达载体系统生产的产品的批准为新型生物制药，特别是人类治疗药物和疫苗带来了希望，有望改善人类健康并提高数百万人的生活质量。
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