Kamath J M, Britigan B E, Cox C D, Shasby D M
Veterans Administration Hospital, Iowa City, Iowa, USA.
Infect Immun. 1995 Dec;63(12):4921-3. doi: 10.1128/iai.63.12.4921-4923.1995.
Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might after vascular homeostasis in the absence of cytolysis.
铜绿假单胞菌肺炎可导致小肺动脉血管炎。虽然完全发展的病变表现为血管壁坏死，但早期病变的显著特点是尽管细菌侵犯血管壁，仍保留有存活的内皮细胞。绿脓菌素是铜绿假单胞菌的一种外毒素产物，可显著抑制肺动脉内皮细胞产生前列环素，且不会导致细胞裂解。在无细胞溶解的情况下，绿脓菌素可能会破坏血管稳态。
