在因卡氏肺孢子虫肺炎接受评估的HIV阳性患者的呼吸道标本中分离出铜绿假单胞菌。
Recovery of Pseudomonas aeruginosa in respiratory specimens from HIV positive patients being evaluated for Pneumocystis carinii pneumonia.
作者信息
Doyle R L, Doherty J J, Zimmerman L H
机构信息
Cardiovascular Research Institute, University of California at San Francisco, USA.
出版信息
Thorax. 1995 May;50(5):548-50. doi: 10.1136/thx.50.5.548.
BACKGROUND
Despite the immune suppression, frequent hospital admissions, and many intercurrent illnesses associated with HIV infection, Pseudomonas aeruginosa has been cited relatively infrequently as a respiratory pathogen in HIV positive patients.
METHODS
The microbiological isolates, medical records, radiographic reports, and laboratory data from 224 patients undergoing sputum induction and/or bronchoalveolar lavage for evaluation of respiratory symptoms suspicious for Pneumocystis carinii pneumonia (PCP) from 1989 to 1992 were reviewed retrospectively.
RESULTS
An increasing number of respiratory isolates with Pseudomonas aeruginosa was found over this time period. Eighteen of the 224 patients were identified in whom P aeruginosa was recovered on at least one occasion. These patients were more likely to have a history of smoking and prior PCP than those in whom Pseudomonas was not recovered. Mean CD4 counts were also significantly lower in these patients.
CONCLUSIONS
Pseudomonas aeruginosa may be recovered from a substantial number of respiratory isolates from HIV positive patients suspected of having PCP. The prevalence of this phenomenon may be increasing.
背景
尽管存在免疫抑制、频繁住院以及许多与HIV感染相关的并发疾病，但铜绿假单胞菌作为HIV阳性患者的呼吸道病原体被提及的频率相对较低。
方法
回顾性分析了1989年至1992年间224例因疑似卡氏肺孢子虫肺炎（PCP）的呼吸道症状而接受痰液诱导和/或支气管肺泡灌洗评估的患者的微生物分离株、病历、影像学报告和实验室数据。
结果
在此期间发现呼吸道分离出铜绿假单胞菌的数量不断增加。224例患者中有18例至少有一次分离出铜绿假单胞菌。与未分离出铜绿假单胞菌的患者相比，这些患者更有可能有吸烟史和既往PCP病史。这些患者的平均CD4细胞计数也显著更低。
结论
在疑似患有PCP的HIV阳性患者的大量呼吸道分离株中可能会分离出铜绿假单胞菌。这种现象的发生率可能正在上升。
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