Luo Y, Shepherd I, Li J, Renzi M J, Chang S, Raper J A
Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Neuron. 1995 Jun;14(6):1131-40. doi: 10.1016/0896-6273(95)90261-9.
Signaling molecules with either attractive or repulsive effects on specific growth cones are likely to play a role in guiding axons to their appropriate targets. A chick brain glycoprotein, collapsin, has been shown to be a good candidate for a repulsive guidance cue. We report here the discovery of four new molecules related to collapsin in chick brains. All contain a semaphorin domain. One is structurally very similar to collapsin but is only 50% identical in its amino acid sequence. We have named it collapsin-2. The collapsin-related genes exhibit distinct but overlapping patterns of mRNA expression in the developing spinal cord and the developing visual system. This family of collapsin-related molecules could potentially act as repulsive cues toward specific neuronal populations.
对特定生长锥具有吸引或排斥作用的信号分子可能在引导轴突到达其合适靶点的过程中发挥作用。一种鸡脑糖蛋白——萎缩蛋白，已被证明是一种很好的排斥性导向线索候选物。我们在此报告在鸡脑中发现了四种与萎缩蛋白相关的新分子。它们都含有一个信号素结构域。其中一种在结构上与萎缩蛋白非常相似，但氨基酸序列只有50%相同。我们将其命名为萎缩蛋白-2。与萎缩蛋白相关的基因在发育中的脊髓和发育中的视觉系统中呈现出不同但重叠的mRNA表达模式。这个与萎缩蛋白相关的分子家族可能对特定神经元群体起到排斥性线索的作用。
