Inagaki S, Furuyama T, Iwahashi Y
Department of Laboratory Sciences, School of Allied Health Sciences, Osaka University Faculty of Medicine, Japan.
FEBS Lett. 1995 Aug 21;370(3):269-72. doi: 10.1016/0014-5793(95)00850-9.
Grasshopper semaphorin I (Sema I) and its related proteins, chick collapsin and mouse Sema III contribute to the axon guidance by their repellent actions [5,9,12]. We have identified a member of semaphorin gene family from the mouse brain and named it M-Sema F. The N-terminal encodes a semaphorin domain that is similar between Sema I-III [6] followed by a single putative immunoglobulin-like domain, a transmembrane domain, and a proline-rich intracellular domain. M-Sema F mRNA is expressed widely in the nervous tissues during development. These suggest that M-Sema F is a transmembrane member of the semaphorin family of the vertebrate which may function in the developing neuronal network.
蚱蜢信号素I（Sema I）及其相关蛋白，鸡的塌陷蛋白和小鼠的信号素III通过其排斥作用对轴突导向起作用[5,9,12]。我们从小鼠脑中鉴定出信号素基因家族的一个成员，并将其命名为M-Sema F。其N端编码一个信号素结构域，该结构域在信号素I-III之间相似[6]，随后是一个单一的假定免疫球蛋白样结构域、一个跨膜结构域和一个富含脯氨酸的细胞内结构域。M-Sema F mRNA在发育过程中广泛表达于神经组织中。这些表明M-Sema F是脊椎动物信号素家族的一个跨膜成员，可能在发育中的神经网络中发挥作用。
