Silverstein M N, ReMine W H
Blood. 1979 Mar;53(3):515-8.
Between 1960 and 1977, 50 patients with agnogenic myeloid metaplasia were splenectomized. Twenty-five of 26 patients with painful splenomegaly, 4 of 9 patients with refractory hemolytic anemia, 4 of 10 patients with refractory thrombocytopenia, and 4 of 4 patients with portal hypertension showed significant benefit from the procedure. There were five immediate postoperative deaths. Four of these deaths occurred early in our series of splectomies for myeloid metaplasia before 1970. Only one death has occurred in the last 21 patients operated on. Survival following splenectomy averaged 25.5 mo.
1960年至1977年间，50例原发性骨髓化生患者接受了脾切除术。26例伴有疼痛性脾肿大的患者中有25例、9例难治性溶血性贫血患者中有4例、10例难治性血小板减少症患者中有4例以及4例门静脉高压患者中有4例从该手术中获益显著。术后有5例即刻死亡。其中4例死亡发生在1970年之前我们一系列骨髓化生脾切除术的早期。在最近接受手术的21例患者中仅发生了1例死亡。脾切除术后的平均生存期为25.5个月。
