Arunodaya G R, Taly A B
Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore, India.
J Neurol Sci. 1995 Apr;129(2):81-9. doi: 10.1016/0022-510x(94)00265-p.
Sympathetic skin response (SSR) is a simple, reproducible test of function of a polysynaptic reflex having diverse afferents, a common efferent pathway through the spinal cord, pre and post-ganglionic sympathetic fibers and with sweat glands as effectors. The reflex is co-ordinated in the posterior hypothalamus or upper brainstem reticular formation. It has been used in a variety of disorders of peripheral and central nervous system. Methodology, possible anatomic substrates, changes in SSR in various diseases and their correlation with clinical features of dysautonomia, bed side tests for dysautonomia and other electrophysiological parameters are critically evaluated. Almost a decade after the start of its widespread clinical utilization, several aspects of SSR remain inconclusive. A consensus as to what change in SSR to consider abnormal is yet to be reached. Though its ease of application supersedes a variety of other autonomic function tests, relying only on SSR changes for prognostication or therapeutic decisions appears impracticable. A battery of tests is thus a necessity.
交感皮肤反应（SSR）是一种简单且可重复的多突触反射功能测试，该反射具有多种传入神经、通过脊髓的共同传出通路、节前和节后交感神经纤维，并以汗腺作为效应器。该反射在下丘脑后部或上脑干网状结构中协调。它已被用于多种外周和中枢神经系统疾病。本文对SSR的方法学、可能的解剖学基础、各种疾病中SSR的变化及其与自主神经功能障碍临床特征的相关性、自主神经功能障碍的床边测试以及其他电生理参数进行了严格评估。在SSR开始广泛临床应用近十年后，其几个方面仍无定论。对于SSR的何种变化应被视为异常尚未达成共识。尽管其应用简便性优于其他多种自主神经功能测试，但仅依靠SSR变化进行预后或治疗决策似乎不可行。因此，一系列测试是必要的。
