Peduzzi P, Holford T, Hardy R
Comput Programs Biomed. 1979 Mar;9(2):106-14. doi: 10.1016/0010-468x(79)90024-2.
This paper presents a computer program for analyzing time-dependent covariables in survival studies by the life table regression model described by Holford [3]. Basically, life table regression incorporates the elements of regression and the life table into a single model. Regression parameters are estimated by the method of maximum likelihood using the Newton-Raphson iterative procedure. The program provides two methods for testing hypotheses concerning regression coefficients, namely the standard normal deviate test and a Wald statistic based on the first and second derivatives of the log likelihood. Residual plots are provided to assess the fit of the model to the data.
本文介绍了一个计算机程序，用于通过霍尔福德[3]描述的生命表回归模型分析生存研究中随时间变化的协变量。基本上，生命表回归将回归元素和生命表纳入一个单一模型。使用牛顿-拉弗森迭代程序通过最大似然法估计回归参数。该程序提供了两种检验关于回归系数假设的方法，即标准正态偏差检验和基于对数似然一阶和二阶导数的 Wald 统计量。提供残差图以评估模型对数据的拟合度。
