Greenstein D, Gupta N K, Martin P, Walker D R, Kester R C
Department of Vascular Surgery, Seacroft Hospital, Leeds.
Angiology. 1995 Jul;46(7):603-11. doi: 10.1177/000331979504600707.
In an attempt to examine the role of the thermoregulatory apparatus in the etiology of Raynaud's phenomenon (RP), the authors exposed 15 women with RP and 12 controls to central body cooling and central body warming. Subjects were placed in an environmental chamber at 25 degrees C. Their right hand was placed in an annex of the chamber, which was insulated from the main chamber and maintained at a constant temperature of 25 degrees C throughout the experiment. Blood flow was measured in the digits of the right hand by venous occlusion strain gauge plethysmography and skin thermometry. Body temperature was measured with an oral thermometer. The temperature of the chamber was then increased to 35 degrees C and then reduced to 13 degrees C for twenty-five minutes with measurements repeated. Following this period patients were rewarmed in an ambient temperature of 35 degrees C for twenty minutes.
subjects with RP had significantly lower blood flow at all stages of the test; moreover, their digital rewarming response following central cooling was considerably prolonged when compared with controls. Body temperature was lower and dropped significantly more in the RP group following the cold challenge. The authors conclude that subjects with RP have an impaired thermoregulatory mechanism. This may partially explain cold sensitivity.
为了研究体温调节机制在雷诺现象（RP）病因中的作用，作者让15名患有RP的女性和12名对照者接受中心体温冷却和中心体温加热。受试者被置于25摄氏度的环境舱中。他们的右手放在舱室的一个附件中，该附件与主舱室隔热，在整个实验过程中保持在25摄氏度的恒定温度。通过静脉阻塞应变计体积描记法和皮肤温度测量法测量右手手指的血流量。用口腔温度计测量体温。然后将舱室温度升至35摄氏度，再降至13摄氏度，持续25分钟，并重复测量。在此期间后，患者在35摄氏度的环境温度下复温20分钟。
患有RP的受试者在测试的所有阶段血流量均显著较低；此外，与对照组相比，他们在中心冷却后的手指复温反应明显延长。在冷刺激后，RP组的体温较低且下降幅度明显更大。作者得出结论，患有RP的受试者体温调节机制受损。这可能部分解释了冷敏感性。
