Alvarado M C, Rudy J W
Department of Psychology, University of Colorado, Boulder 80309, USA.
Behav Neurosci. 1995 Dec;109(6):1052-62. doi: 10.1037//0735-7044.109.6.1052.
J.W. Rudy and R.J. Sutherland (1989) suggested that the hippocampal formation (HF) is necessary for performance of configural tasks and that rats with kainic acid + colchicine (K-C) damage to the HF were impaired on the negative patterning problem (A+, B+, AB-). However, M. Gallagher and P.C. Holland (1992) found spared performance on a similar task (AC+, B+, AB-, C-) when ibotenic acid (IBO) was used. This study compared the effects of K-C- and IBO-induced HF damage on 4 configural tasks: (a) negative patterning, (b) the Gallagher-Holland task, (c) transverse patterning, and (d) place learning. Rats with IBO lesions performed like controls on the Gallagher-Holland task (replicating M. Gallagher & P.C. Holland) but were impaired on negative patterning, transverse patterning, and place learning. In contrast, rats with K-C lesions were impaired on all 4 tasks. The implications of these results for theories of HF function are discussed.
J.W. 鲁迪和R.J. 萨瑟兰（1989年）提出，海马结构（HF）对于构型任务的执行是必要的，并且用 kainic 酸 + 秋水仙碱（K-C）损伤HF的大鼠在负性模式问题（A+、B+、AB-）上表现受损。然而，M. 加拉格尔和P.C. 霍兰德（1992年）发现，当使用鹅膏蕈氨酸（IBO）时，在类似任务（AC+、B+、AB-、C-）上表现得以保留。本研究比较了K-C和IBO诱导的HF损伤对4种构型任务的影响：（a）负性模式，（b）加拉格尔 - 霍兰德任务，（c）横向模式，以及（d）位置学习。IBO损伤的大鼠在加拉格尔 - 霍兰德任务上的表现与对照组相似（重复了M. 加拉格尔和P.C. 霍兰德的结果），但在负性模式、横向模式和位置学习上表现受损。相比之下，K-C损伤的大鼠在所有4项任务上均表现受损。讨论了这些结果对HF功能理论的意义。
