Nomori H, Horio H, Fuyuno G, Kobayashi R, Morinaga S, Hirabayashi Y
Department of Surgery, Saiseikai Central Hospital, Tokyo, Japan.
Am J Respir Crit Care Med. 1995 Aug;152(2):746-50. doi: 10.1164/ajrccm.152.2.7633737.
Serum levels of protein 1 (P1), a Clara cell secretory protein, were studied in 942 healthy subjects in relation to sex, age, and smoking habits and in 117 patients with bacterial pneumonia in relation to prognosis. P1 values in bacterial pneumonia patients at disease onset were compared with those in 234 healthy control subjects matched by sex and age. P1 values in healthy males were highest in those 30 to 39 yr of age and highest in healthy females > or = 70 yr of age but lowest in those 30 to 49 yr of age. P1 values in healthy males were significantly higher than those in females in the 30- to 39-yr age group (p < 0.05). Male smokers showed higher P1 values than nonsmokers, but without a significant difference. P1 values in patients with pneumonia were significantly lower than in control subjects (p < 0.0001). P1 values were significantly lower in patients treated with a respirator than in in patients treated without a respirator (p < 0.05). In 59 patients, whose P1 values could be followed up until the outcome of pneumonia, all 37 recovered patients showed significantly increased P1 values after recovery (p < 0.001), and all 22 who died of their illness showed significantly decreased P1 values just before death (p < 0.01). We thus conclude that P1 serum levels were significantly affected by sex and by the degree of seriousness in bacterial pneumonia.
研究了942名健康受试者血清中克拉拉细胞分泌蛋白1（P1）水平与性别、年龄和吸烟习惯的关系，并研究了117例细菌性肺炎患者血清P1水平与预后的关系。将细菌性肺炎患者发病时的P1值与234名按性别和年龄匹配的健康对照者的P1值进行比较。健康男性的P1值在30至39岁年龄组中最高，健康女性≥70岁时最高，但在30至49岁年龄组中最低。在30至39岁年龄组中，健康男性的P1值显著高于女性（p<0.05）。男性吸烟者的P1值高于不吸烟者，但无显著差异。肺炎患者的P1值显著低于对照组（p<0.0001）。使用呼吸机治疗的患者的P1值显著低于未使用呼吸机治疗的患者（p<0.05）。在59例P1值可随访至肺炎转归的患者中，所有37例康复患者康复后P1值显著升高（p<0.001），所有22例死亡患者在死亡前P1值显著降低（p<0.01）。因此，我们得出结论，P1血清水平受性别和细菌性肺炎严重程度的显著影响。
