Nomori H, Horio H, Kobayashi R, Morinaga S
Department of Surgery, Saiseikai Central Hospital, Minato-ku, Tokyo, Japan.
Surg Today. 1997;27(2):124-9. doi: 10.1007/BF02385900.
Serum levels of protein 1 (P1), a Clara cell protein known to have an antiinflammatory effect, were studied in 33 patients with lung cancer before surgery, and 3, 7, 14, 21 days, and 2 months after surgery. The preoperative P1 values of the lung cancer patients were compared with those of 66 healthy controls matched by sex and age. The postoperative changes in P1 which occurred in the lung cancer patients were compared with those in 16 patients who underwent laparotomy for gastric or colon cancer. There was no significant difference in the P1 values between the lung cancer patients and the healthy controls; however, the postoperative P1 values showed a significant decrease 3, 7, (P < 0.001), and 14 days (P < 0.05) postoperatively, recovering to normal within 2 months after surgery. One patient who died of postoperative pneumonia showed decreasing serum P1 levels until death. None of the laparotomy patients showed any decrease in P1 serum levels. Thus, we conclude that: (a) serum P1 levels do not differ between lung cancer patients and healthy individuals; (b) serum P1 levels significantly decrease in the early postoperative period, but recover within 2 months after lung resection; and (c) the postoperative changes that occur in serum P1 levels could provide important information about recovery from intraoperative lung damage.
对33例肺癌患者术前、术后3天、7天、14天、21天及2个月时血清中蛋白1（P1）水平进行了研究，P1是一种已知具有抗炎作用的克拉拉细胞蛋白。将肺癌患者术前的P1值与66名年龄和性别匹配的健康对照者的P1值进行比较。将肺癌患者术后P1的变化与16例因胃癌或结肠癌接受剖腹手术患者的变化进行比较。肺癌患者与健康对照者的P1值无显著差异；然而，术后3天、7天（P<0.001）和14天（P<0.05）时P1值显著下降，术后2个月内恢复正常。1例死于术后肺炎的患者血清P1水平直至死亡一直下降。所有接受剖腹手术的患者血清P1水平均未下降。因此，我们得出结论：（a）肺癌患者与健康个体的血清P1水平无差异；（b）术后早期血清P1水平显著下降，但肺切除术后2个月内恢复；（c）血清P1水平的术后变化可为术中肺损伤的恢复提供重要信息。
