Mattsson C, Magnuson K, Hellström S
Department of Otorhinolaryngology, University of Umeå, Sweden.
Ann Otol Rhinol Laryngol. 1995 Aug;104(8):625-32. doi: 10.1177/000348949510400807.
The purpose of this study was to elucidate possible relationships between the oxygen concentration of the middle ear cavity and the development of myringosclerosis. Three groups of rats with myringotomized tympanic membranes were exposed to different oxygen concentrations of 10%, 15%, and 40%, respectively, for 1 week. A fourth group was kept in ambient air. Two other groups of rats with myringotomized and intubated tympanic membranes were exposed to oxygen concentrations of 10% and 40%, respectively, for the same period of time. Otomicroscopically, all hyperoxic animals had more numerous myringosclerotic lesions compared with the ambient air group, and also displayed a pronounced hyperplasia of the keratinizing epithelium around the perforation border. By contrast, the hypoxic animals showed less pronounced myringosclerotic lesions or even completely lacked them. It is inferred that an increased oxygen concentration in the middle ear cavity will increase the likelihood of myringosclerotic deposits. The mechanism involved could be related to the formation of oxygen radicals.
本研究的目的是阐明中耳腔氧浓度与鼓膜硬化症发展之间可能存在的关系。将三组鼓膜切开的大鼠分别暴露于10%、15%和40%的不同氧浓度环境中1周。第四组置于空气中。另外两组鼓膜切开并插管的大鼠在相同时间段内分别暴露于10%和40%的氧浓度环境中。耳显微镜检查显示，与空气组相比，所有高氧环境下的动物鼓膜硬化病变更多，穿孔边缘角质化上皮也有明显增生。相比之下，低氧环境下的动物鼓膜硬化病变不明显，甚至完全没有。据推测，中耳腔氧浓度升高会增加鼓膜硬化沉积物形成的可能性。其中涉及的机制可能与氧自由基的形成有关。
