继发于干扰素α的前部缺血性视神经病变
Anterior ischemic optic neuropathy secondary to interferon alfa.
作者信息
Purvin V A
机构信息
Midwest Eye Institute/Methodist Hospital of Indiana, Indianapolis, USA.
出版信息
Arch Ophthalmol. 1995 Aug;113(8):1041-4. doi: 10.1001/archopht.1995.01100080093034.
OBJECTIVE
To report the occurrence of anterior ischemic optic neuropathy as a complication of treatment with interferon alfa and to consider the possible underlying mechanisms for this association.
DESIGN
Description of the clinical findings in two patients with this condition.
SETTING
A neuro-ophthalmology referral center.
PATIENTS
Two patients, ages 40 and 51 years, undergoing treatment with interferon alfa for malignant neoplasms experienced sudden bilateral, sequential visual loss with disc-related field defects and segmental optic disc edema.
INTERVENTIONS
Treatment with aspirin and prednisone in one patient.
MAIN OUTCOME MEASURES
Visual acuity, color vision, Goldmann perimetry testing, and fundus photography.
RESULTS
Visual loss was mild and generally nonprogressive. The interval between initiating treatment with interferon alfa and onset of anterior ischemic optic neuropathy was similar to that of interferon-associated vascular retinopathy.
CONCLUSION
Anterior ischemic optic neuropathy may complicate treatment with interferon alfa. The underlying pathogenesis is probably multifactorial.
目的
报告前缺血性视神经病变作为干扰素α治疗并发症的发生情况，并探讨这种关联可能的潜在机制。
设计
对两名患有这种疾病患者的临床发现进行描述。
地点
一个神经眼科转诊中心。
患者
两名年龄分别为40岁和51岁的患者，正在接受干扰素α治疗恶性肿瘤，出现双侧突然、相继的视力丧失，伴有与视盘相关的视野缺损和节段性视盘水肿。
干预措施
一名患者接受阿司匹林和泼尼松治疗。
主要观察指标
视力、色觉、Goldmann视野检查和眼底照相。
结果
视力丧失较轻且通常无进展。开始使用干扰素α治疗至前缺血性视神经病变发作的间隔与干扰素相关的视网膜血管病变相似。
结论
前缺血性视神经病变可能是干扰素α治疗的并发症。潜在发病机制可能是多因素的。
Zotero 插件