Rocha G, Veríssimo A, Bowker R, Bornstein N, Da Costa M S
Faculdade de Medicina, Universidade de Coimbra, Portugal.
Epidemiol Infect. 1995 Aug;115(1):79-88. doi: 10.1017/s0950268800058143.
The presence of Legionella spp. in the water of a Portuguese spa was ascertained during the spa season, between May and November. Simultaneously the prevalence of anti-legionella antibodies in people attending the spa was also investigated. The antibody titres of 172 randomly selected patients and 42 therapists were determined, and compared with a control group of 503 blood donors. Legionellae were present in the spa water at low concentrations, generally lower than 10(3) c.f.u./l. A total of 92 strains representing eight different species or serogroups were isolated; the predominant isolates belonged to Legionella pneumophila serogroup 6 and to L. londiniensis. During the study, no clinical cases of Legionnaires' disease were observed, and the antibody titres were generally low in the groups studied. However, the antibody titres of the patients increased slightly during their stay at the spa, approaching the values for the therapists. Mean antibody titres in the groups related with the spa were significantly higher than those in the blood donors against five of the seven legionella antigens tested. The largest number of elevated antibody titres in the exposed groups were to the L. pneumophila sg 5 and sg 6 antigens.
在5月至11月的温泉疗养季节期间，确定了葡萄牙一家温泉浴场水中存在嗜肺军团菌属。同时，还对前往该温泉浴场的人群中抗军团菌抗体的流行情况进行了调查。测定了172名随机选择的患者和42名治疗师的抗体滴度，并与503名献血者组成的对照组进行了比较。温泉浴场水中存在低浓度的军团菌，一般低于10³ c.f.u./l。共分离出代表8个不同种或血清群的92株菌株；主要分离株属于嗜肺军团菌血清群6和伦敦军团菌。在研究期间，未观察到军团病的临床病例，且在所研究的组中抗体滴度一般较低。然而，患者在温泉浴场停留期间抗体滴度略有升高，接近治疗师的水平。与温泉浴场相关的组中，针对所检测的7种军团菌抗原中的5种，其平均抗体滴度显著高于献血者。暴露组中抗体滴度升高最多的是针对嗜肺军团菌血清型5和血清型6抗原。
