Fibre-optical sensor based on fluorescent indicator for monitoring physiological pH values.

作者信息

Zhang S, Tanaka S, Wickramasinghe Y A, Rolfe P

机构信息

Department of Biomedical Engineering & Medical Physics, Keele-University, North Staffordshire Hospital, Stoke-on-Trent, UK.

出版信息

Med Biol Eng Comput. 1995 Mar;33(2):152-6. doi: 10.1007/BF02523033.

DOI:10.1007/BF02523033

PMID:7643652

Abstract

A fibre-optical sensor has been developed based on the fluorescent indicator 8-hydroxyl-1,3,6-pyrene trisulphonic acid trisodium salt (HOPSA) for monitoring physiological pH values. Dowex-1 strongly basic anion exchange resin is used as the medium to immobilise the indicator on the end of an optical fibre. Polyurethane is coated on the sensor as the permeable membrane for H+. The properties of HOPSA in solution, as well as when immobilised on the sensor, are studied and found to have the potential for monitoring physiological pH values.

摘要