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Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA).肿瘤坏死因子-α（TNF-α）阻断剂在类风湿关节炎（RA）中的有益作用。
Clin Exp Immunol. 1995 Aug;101(2):207-12. doi: 10.1111/j.1365-2249.1995.tb08340.x.
2
Targeting TNF alpha for the therapy of rheumatoid arthritis.以肿瘤坏死因子α为靶点治疗类风湿关节炎。
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3
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.单克隆抗TNFα抗体作为类风湿性疾病发病机制及治疗的一种探针。
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5
Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned?类风湿关节炎的抗肿瘤坏死因子α治疗：我们学到了什么？
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J Immunol. 1991 May 15;146(10):3365-71.

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Tumor necrosis factor (TNF) induces astrogliosis, microgliosis and promotes survival of cortical neurons.肿瘤坏死因子（TNF）可诱导星形胶质细胞增生、小胶质细胞增生，并促进皮质神经元的存活。
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本文引用的文献

1
Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha.用抗肿瘤坏死因子α嵌合单克隆抗体治疗类风湿性关节炎。
Arthritis Rheum. 1993 Dec;36(12):1681-90. doi: 10.1002/art.1780361206.
2
Construction and initial characterization of a mouse-human chimeric anti-TNF antibody.小鼠-人嵌合抗TNF抗体的构建及初步表征
Mol Immunol. 1993 Nov;30(16):1443-53. doi: 10.1016/0161-5890(93)90106-l.
3
New directions for biological therapy in rheumatoid arthritis.
Int Arch Allergy Immunol. 1994;104(2):112-25. doi: 10.1159/000236718.
4
Immunoregulatory role of interleukin 10 in rheumatoid arthritis.白细胞介素10在类风湿性关节炎中的免疫调节作用。
J Exp Med. 1994 May 1;179(5):1517-27. doi: 10.1084/jem.179.5.1517.
5
Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis.肿瘤坏死因子α单克隆抗体（cA2）对类风湿性关节炎患者的重复治疗。
Lancet. 1994 Oct 22;344(8930):1125-7. doi: 10.1016/s0140-6736(94)90632-7.
6
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis.嵌合型肿瘤坏死因子α单克隆抗体（cA2）与安慰剂治疗类风湿关节炎的随机双盲对照研究
Lancet. 1994 Oct 22;344(8930):1105-10. doi: 10.1016/s0140-6736(94)90628-9.
7
Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4.用肿瘤坏死因子受体-IgG融合蛋白及联合抗CD4治疗胶原诱导性关节炎取得成功。
Immunology. 1995 Mar;84(3):433-9.
8
Immunological intervention reveals reciprocal roles for tumor necrosis factor-alpha and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus.免疫干预揭示了肿瘤坏死因子-α和白细胞介素-10在类风湿关节炎和系统性红斑狼疮中的相互作用。
Springer Semin Immunopathol. 1994;16(2-3):327-36. doi: 10.1007/BF00197526.
9
Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease.单克隆抗TNFα抗体作为类风湿性疾病发病机制及治疗的一种探针。
Immunol Rev. 1995 Apr;144:195-223. doi: 10.1111/j.1600-065x.1995.tb00070.x.
10
Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha.类风湿关节炎中白细胞介素-1和肿瘤坏死因子信使核糖核酸的表达：白细胞介素-1α的持续产生
Clin Exp Immunol. 1988 Sep;73(3):449-55.

肿瘤坏死因子-α（TNF-α）阻断剂在类风湿关节炎（RA）中的有益作用。

Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA).

作者信息

Maini R N, Elliott M J, Brennan F M, Feldmann M

机构信息

Kennedy Institute of Rheumatology, London, UK.

出版信息

Clin Exp Immunol. 1995 Aug;101(2):207-12. doi: 10.1111/j.1365-2249.1995.tb08340.x.

DOI:10.1111/j.1365-2249.1995.tb08340.x
PMID:7648705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1553280/
Abstract

The biological properties of TNF-alpha make it a candidate therapeutic target in RA. Our studies have demonstrated that TNF-alpha and its receptors are up-regulated and co-expressed in the synovium and cartilage-pannus junction of RA joints. Neutralizing TNF-alpha antibodies reduce the production of the many pro-inflammatory cytokines, including IL-1 and granulocyte-macrophage colony-stimulating factor (GM-CSF), produced by mononuclear cells from RA in culture. When injected into DBA/1 mice with collagen-induced arthritis and TNF-alpha transgenic mice with arthritis, anti-TNF MoAbs decrease inflammatory damage of joints. Clinical trials employing cA2, a chimaeric anti-TNF-alpha MoAb, in open-label and randomized placebo-controlled studies have demonstrated a dose-dependent efficacy with impressive improvement in disease activity and acute-phase responses lasting several weeks. We conclude that TNF-alpha is a critical mediator of inflammation in RA, and is an important therapeutic target in this disease.

摘要

肿瘤坏死因子-α（TNF-α）的生物学特性使其成为类风湿关节炎（RA）的一个候选治疗靶点。我们的研究表明，TNF-α及其受体在RA关节的滑膜和软骨-血管翳交界处上调并共同表达。中和TNF-α抗体可减少培养的RA单核细胞产生的多种促炎细胞因子，包括白细胞介素-1（IL-1）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）。当注射到胶原诱导性关节炎的DBA/1小鼠和患有关节炎的TNF-α转基因小鼠中时，抗TNF单克隆抗体可减少关节的炎症损伤。在开放标签和随机安慰剂对照研究中使用嵌合抗TNF-α单克隆抗体cA2的临床试验表明，其具有剂量依赖性疗效，疾病活动和急性期反应有显著改善，且持续数周。我们得出结论，TNF-α是RA炎症的关键介质，也是该疾病的重要治疗靶点。