Vaira D, Miglioli M, Menegatti M, Holton J, Boschini A, Vergura M, Ricci C, Azzarone P, Mulè P, Barbara L
1st Medical Clinic, University of Bologna, Italy.
Dig Dis Sci. 1995 Aug;40(8):1622-6. doi: 10.1007/BF02212680.
We have carried out a large prospective study of the frequency of H. pylori infection and HIV-1 status in a community of ex-drug abusers including subjects with (N = 210) and without (N = 259) upper gastrointestinal symptoms, endoscopy and serology. Control groups were patients with upper gastrointestinal symptoms not at high risk of HIV-1 infection (N = 219) and asymptomatic blood donors (n = 322). H. pylori was present in 52% of symptomatic community residents having endoscopy and 55% of the control patients with symptoms but not at high risk of HIV-1 infection. H. pylori was less common in HIV-1-positive patients (40%) than those who were negative (66%; P < 0.001). In patients with AIDS (33%), the frequency of H. pylori infection was reduced compared to HIV-1-positive patients without AIDS (53%; P = 0.05). All the residents with AIDS had upper gastrointestinal symptoms. In community residents, peptic ulcer was always associated with H. pylori infection. By H. pylori serology, there was no difference in the frequency of infection in asymptomatic residents (56%) whether HIV-1 positive (55%) or HIV-1 negative (58%) compared with those residents with symptoms. Overall, H. pylori was less common in HIV-1-positive residents (49%) than those who were HIV-1 negative (61%; p < 0.05). This difference was due mainly to the low frequency of infection in residents with AIDS (33%). H. pylori infection is common in HIV-1 positive patients, and only slightly reduced when compared with at-risk HIV-1-negative subjects. Peptic ulcer is associated with H. pylori in HIV-1 infection.(ABSTRACT TRUNCATED AT 250 WORDS)
我们对一个戒毒者社区进行了一项大型前瞻性研究，调查幽门螺杆菌感染频率及HIV-1感染状况，该社区包括有（N = 210）和无（N = 259）上消化道症状的受试者，并进行了内镜检查和血清学检测。对照组为无上消化道症状且无HIV-1感染高风险的患者（N = 219）和无症状献血者（n = 322）。接受内镜检查的有症状社区居民中，52%存在幽门螺杆菌感染；有症状但无HIV-1感染高风险的对照患者中，这一比例为55%。HIV-1阳性患者中幽门螺杆菌感染率（40%）低于HIV-1阴性患者（66%；P < 0.001）。与无艾滋病的HIV-1阳性患者相比，艾滋病患者中幽门螺杆菌感染率降低（33%对53%；P = 0.05）。所有艾滋病居民均有上消化道症状。在社区居民中，消化性溃疡总是与幽门螺杆菌感染相关。通过幽门螺杆菌血清学检测，无症状居民中，无论HIV-1阳性（55%）还是HIV-1阴性（58%），其感染频率与有症状居民相比无差异。总体而言，HIV-1阳性居民中幽门螺杆菌感染率（49%）低于HIV-1阴性居民（61%；p < 0.05）。这种差异主要是由于艾滋病居民感染率较低（33%）。幽门螺杆菌感染在HIV-1阳性患者中很常见，与有感染风险的HIV-1阴性受试者相比仅略有降低。在HIV-1感染中，消化性溃疡与幽门螺杆菌有关。（摘要截选至250词）
