Vaira D, Miglioli M, Mulè P, Holton J, Menegatti M, Vergura M, Biasco G, Conte R, Logan R P, Barbara L
1st Medical Clinic, University of Bologna, Italy.
Gut. 1994 Mar;35(3):309-12. doi: 10.1136/gut.35.3.309.
This study aimed to determine the importance of raised antibodies to Helicobacter pylori in an asymptomatic population. A total of 128 asymptomatic blood donors who were seropositive for H pylori and consented to endoscopy were investigated. These subjects were from a population of 1010 blood donors screened for antibodies to H pylori. A questionnaire was completed to determine if any subjects had complained of symptoms, and they subsequently had endoscopy. Altogether 121 of 128 were positive for H pylori by histology and urease test and/or culture and all 121 had chronic active gastritis on histology. Twenty five of these subjects had peptic ulcer (20 duodenal, five gastric), a further 21 had erosive duodenitis, and two were found to have gastric cancer. H pylori associated peptic ulcer disease and duodenitis occur more frequently than previously recognised and this suggests that H pylori infection, even if asymptomatic, is of far greater clinical relevance than originally thought.
本研究旨在确定在无症状人群中幽门螺杆菌抗体升高的重要性。对128名幽门螺杆菌血清学阳性且同意接受内镜检查的无症状献血者进行了调查。这些受试者来自1010名接受幽门螺杆菌抗体筛查的献血者群体。完成一份问卷以确定是否有受试者曾抱怨有症状，随后他们接受了内镜检查。128名受试者中共有121名经组织学和尿素酶试验及/或培养显示幽门螺杆菌呈阳性，且所有121名受试者组织学检查均有慢性活动性胃炎。其中25名受试者患有消化性溃疡（20例十二指肠溃疡，5例胃溃疡），另有21名患有糜烂性十二指肠炎，2名被发现患有胃癌。幽门螺杆菌相关的消化性溃疡疾病和十二指肠炎的发生率比之前认为的更高，这表明幽门螺杆菌感染即使无症状，其临床相关性也远比最初认为的要大得多。
