慢性炎症性肝病发病机制的研究。I. 来自患者的分离肝细胞上的膜固定IgG
Studies on the pathogenesis of chronic inflammatory liver diseases. I. Membrane-fixed IgG on isolated hepatocytes from patients.
作者信息
Hopf U, Arnold W, Meyer zum Büschenfelde K H, Förster E, Bolte J P
出版信息
Clin Exp Immunol. 1975 Oct;22(1):1-8.
Abstract
Membrane-fixed IgG on isolated hepatocytes from biopsy material could be demonstrated by direct immunofluorescence in nine of thirty-four patients with acute virus-B hepatitis and in seventeen of forty-nine cases with chronic active hepatitis (CAH). Patients with acute virus-A hepatitis, chronic persistent hepatitis (CPH) or metabolic liver diseases did not show this phenomenon. Cases with CAH and IgG on the hepatocytes-HBsAg-positive as well as HBsAg-negative-had high inflammatory activity. Antibodies against HBsAg were not present in any serum. Autoimmune phenomena (antibodies against smooth muscle, mitochondria and nuclei) were only rarely demonstrable. The findings suggest that an antibody- or immune complex-mediated lymphocyte cytotoxicity may be involved in the pathogenesis of chronic liver diseases.
摘要
通过直接免疫荧光法可在34例急性乙型病毒性肝炎患者中的9例以及49例慢性活动性肝炎（CAH）患者中的17例活检材料分离的肝细胞上检测到膜固定IgG。急性甲型病毒性肝炎、慢性持续性肝炎（CPH）或代谢性肝病患者未出现此现象。CAH患者肝细胞上存在IgG，无论HBsAg阳性还是阴性，均具有高炎症活性。所有血清中均未检测到抗HBsAg抗体。自身免疫现象（抗平滑肌、线粒体和细胞核抗体）仅偶尔可检测到。这些发现提示抗体或免疫复合物介导的淋巴细胞细胞毒性可能参与慢性肝病的发病机制。
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