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Quantitative competitive PCR with bronchoalveolar lavage fluid for diagnosis of toxoplasmosis in AIDS patients.采用支气管肺泡灌洗液进行定量竞争性聚合酶链反应诊断艾滋病患者弓形虫病
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Detection of Toxoplasma gondii in AIDS patients by the polymerase chain reaction.通过聚合酶链反应检测艾滋病患者中的弓形虫。
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Diagnosis of acute pulmonary toxoplasmosis by visualization of invasive and intracellular tachyzoites in Giemsa-stained smears of bronchoalveolar lavage fluid.通过在支气管肺泡灌洗液体吉姆萨染色涂片中观察侵袭性和细胞内速殖子来诊断急性肺弓形虫病。
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Seroprevalence of Toxoplasma gondii IgG antibody in HIV-infected patients at the Lagos University Teaching Hospital.拉各斯大学教学医院艾滋病毒感染患者弓形虫IgG抗体血清阳性率
HIV AIDS (Auckl). 2011;3:101-5. doi: 10.2147/HIV.S15532. Epub 2011 Sep 5.
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Significant performance variation among PCR systems in diagnosing congenital toxoplasmosis in São Paulo, Brazil: analysis of 467 amniotic fluid samples.巴西圣保罗市不同 PCR 系统诊断先天性弓形虫病的效能差异较大：467 例羊水样本分析。
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Screening for active toxoplasmosis in patients by DNA hybridization with the ABGTg7 probe in blood samples.通过在血液样本中使用ABGTg7探针进行DNA杂交，对患者进行活动性弓形虫病筛查。
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本文引用的文献

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Detection of Toxoplasma gondii by competitive DNA amplification of bronchoalveolar lavage samples.通过支气管肺泡灌洗样本的竞争性DNA扩增检测弓形虫。
J Infect Dis. 1993 Dec;168(6):1585-8. doi: 10.1093/infdis/168.6.1585.
2
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.通过竞争性聚合酶链反应确定，在感染的所有阶段血浆中均存在高水平的HIV-1。
Science. 1993 Mar 19;259(5102):1749-54. doi: 10.1126/science.8096089.
3
Prenatal diagnosis of congenital toxoplasmosis with a polymerase-chain-reaction test on amniotic fluid.采用聚合酶链反应检测羊水进行先天性弓形虫病的产前诊断。
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Toxoplasma gondii infection in advanced HIV infection.
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Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction.通过聚合酶链反应直接灵敏地检测致病原生动物刚地弓形虫。
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6
Combined APACHE II score and serum lactate dehydrogenase as predictors of in-hospital mortality caused by first episode Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome.联合急性生理学及慢性健康状况评分系统II（APACHE II）和血清乳酸脱氢酶作为获得性免疫缺陷综合征患者首次发作卡氏肺孢子虫肺炎所致院内死亡的预测指标。
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Pulmonary toxoplasmosis: a review.肺弓形虫病：综述
Clin Infect Dis. 1992 Apr;14(4):863-70. doi: 10.1093/clinids/14.4.863.
8
Extreme elevations of serum lactic dehydrogenase differentiating pulmonary toxoplasmosis from Pneumocystis pneumonia.
N Engl J Med. 1992 Apr 30;326(18):1226. doi: 10.1056/NEJM199204303261816.
9
The clinical utility of serum lactate dehydrogenase in diagnosing pneumocystis carinii pneumonia among hospitalized AIDS patients.血清乳酸脱氢酶在诊断住院艾滋病患者卡氏肺孢子虫肺炎中的临床应用。
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Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome.获得性免疫缺陷综合征中的中枢神经系统弓形虫病
N Engl J Med. 1992 Dec 3;327(23):1643-8. doi: 10.1056/NEJM199212033272306.

采用支气管肺泡灌洗液进行定量竞争性聚合酶链反应诊断艾滋病患者弓形虫病

Quantitative competitive PCR with bronchoalveolar lavage fluid for diagnosis of toxoplasmosis in AIDS patients.

作者信息

Bretagne S, Costa J M, Fleury-Feith J, Poron F, Dubreuil-Lemaire M L, Vidaud M

机构信息

Laboratoire de Parasitologie-Mycologie, Hôpital Henri Mondor, Créteil, France.

出版信息

J Clin Microbiol. 1995 Jun;33(6):1662-4. doi: 10.1128/jcm.33.6.1662-1664.1995.

DOI:10.1128/jcm.33.6.1662-1664.1995
PMID:7650210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC228241/
Abstract

Of 121 AIDS patients, 12 (10%) had Toxoplasma gondii DNA detected by competitive PCR in their bronchoalveolar lavage samples. Quantitation of the PCR results showed a correlation between the parasite burden and the serum lactic dehydrogenase titer. Quantitative competitive PCR could be useful to assess the diagnosis and the severity of pulmonary toxoplasmosis.

摘要

在121例艾滋病患者中，12例（10%）的支气管肺泡灌洗样本经竞争性聚合酶链反应检测出弓形虫DNA。聚合酶链反应结果的定量分析显示，寄生虫负荷与血清乳酸脱氢酶滴度之间存在相关性。定量竞争性聚合酶链反应可能有助于评估肺弓形虫病的诊断和严重程度。