Mathieu C, Ecochard R, Bied V, Lornage J, Czyba J C
Laboratoire de Biologie de la Reproduction, Hôpital Edouard Herriot, Lyon, France.
Hum Reprod. 1995 May;10(5):1090-7. doi: 10.1093/oxfordjournals.humrep.a136100.
This paper presents the analysis of 901 cycles of intrauterine artificial insemination with the husband's spermatozoa (AIHIU) in 274 couples who obtained 80 pregnancies. The cumulative pregnancy rate after three cycles of AIHIU was 22% and reached 39% after six cycles. Univariate analysis disclosed two factors of poor prognosis: duration of infertility > 3 years (P = 0.01) and husband's age (P = 0.03). Multivariate analysis revealed that the most significant factor contributing to a decreased likelihood of pregnancy was the age of the husband (P = 0.01), then duration of infertility and dysovulation. The wife's age > or = 35 years did not appear to be of poor prognostic value when taking into consideration the three other factors.
