真核生物中的DNA复制：染色质亚基特异性参与的模型
DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits.
作者信息
Hewish D R
出版信息
Nucleic Acids Res. 1976 Jan;3(1):69-78. doi: 10.1093/nar/3.1.69.
Abstract
A model is proposed whereby eukaryotic DNA replication is specifically directed by the 200 base pair repeat structure of the DNA-histone complex. The model proposes a mechanism for the sequential, bidirectional replication of DNA from initial origin points on the chromatin fibre and is consistent with the known properties of eukaryotic DNA replication. Several predictions can be made from the model which are amenable to testing.
摘要
提出了一个模型，据此真核生物DNA复制由DNA - 组蛋白复合物的200个碱基对重复结构特异性指导。该模型提出了一种从染色质纤维上的初始起始点进行DNA顺序双向复制的机制，并且与真核生物DNA复制的已知特性一致。从该模型可以做出几个适合进行测试的预测。
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