细小病毒B19在滑液和骨髓中的持续存在。
Persistence of parvovirus B19 in synovial fluid and bone marrow.
作者信息
Nikkari S, Roivainen A, Hannonen P, Möttönen T, Luukkainen R, Yli-Jama T, Toivanen P
机构信息
Department of Medical Microbiology, Turku University, Finland.
出版信息
Ann Rheum Dis. 1995 Jul;54(7):597-600. doi: 10.1136/ard.54.7.597.
Abstract
OBJECTIVES
To determine whether parvovirus B19 (B19) persists in rheumatoid arthritis (RA).
METHODS
Polymerase chain reaction (PCR) was used to detect parvovirus B19 genome in the synovial fluid cells or peripheral blood mononuclear cells from 61 patients with early RA; bone marrow from one patient was also studied. The synovium or synovial fluid cells from 28 patients with advanced RA, and synovial fluid cell samples from 18 patients with reactive arthritis (as controls) were studied. Two separate sets of primers and probe were used.
RESULTS
Parvovirus B19 specific gene sequences were detected in two patients with early arthritis fulfilling the criteria for RA.
CONCLUSION
Parvovirus B19 does not play a significant role in the aetiopathogenesis of RA. However, a few cases of a disease indistinguishable from RA may be triggered by parvovirus B19 infection.
摘要
目的
确定细小病毒B19（B19）是否在类风湿关节炎（RA）中持续存在。
方法
采用聚合酶链反应（PCR）检测61例早期RA患者滑膜液细胞或外周血单个核细胞中的细小病毒B19基因组；还对1例患者的骨髓进行了研究。对28例晚期RA患者的滑膜或滑膜液细胞以及18例反应性关节炎患者（作为对照）的滑膜液细胞样本进行了研究。使用了两组不同的引物和探针。
结果
在两名符合RA标准的早期关节炎患者中检测到细小病毒B19特异性基因序列。
结论
细小病毒B19在RA的发病机制中不发挥重要作用。然而，少数与RA难以区分的疾病可能由细小病毒B19感染引发。
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本文引用的文献
1
Parvovirus B19 infection.
Rheum Dis Clin North Am. 1993 May;19(2):457-75.
2
Parvovirus B19-specific DNA in bone marrow from B19 arthropathy patients: evidence for B19 virus persistence.细小病毒B19关节炎患者骨髓中细小病毒B19特异性DNA：B19病毒持续存在的证据
J Infect Dis. 1993 Mar;167(3):744-8. doi: 10.1093/infdis/167.3.744.
3
Detection of herpesviruses by polymerase chain reaction in lymphocytes from patients with rheumatoid arthritis.采用聚合酶链反应检测类风湿性关节炎患者淋巴细胞中的疱疹病毒
Arthritis Rheum. 1993 Aug;36(8):1080-6. doi: 10.1002/art.1780360808.
4
Does parvovirus B19 have a role in rheumatoid arthritis?细小病毒B19在类风湿性关节炎中起作用吗？
Ann Rheum Dis. 1994 Feb;53(2):106-11. doi: 10.1136/ard.53.2.106.
5
Wegener's granulomatosis and parvovirus B19 infection.
Arthritis Rheum. 1994 Nov;37(11):1707-8. doi: 10.1002/art.1780371122.
6
Chronic parvovirus B19 infection and systemic necrotising vasculitis: opportunistic infection or aetiological agent?慢性B19细小病毒感染与系统性坏死性血管炎：机会性感染还是病原体？
Lancet. 1994 May 21;343(8908):1255-8. doi: 10.1016/s0140-6736(94)92152-0.
7
Parvovirus B19 and erosive polyarthritis.细小病毒B19与侵蚀性多关节炎
Lancet. 1994 Feb 19;343(8895):480-1. doi: 10.1016/s0140-6736(94)92725-1.
8
Diagnosis of human parvovirus infection by dot-blot hybridization using cloned viral DNA.
J Med Virol. 1985 Feb;15(2):163-72. doi: 10.1002/jmv.1890150209.
9
Human parvovirus arthropathy.人类细小病毒关节炎
Lancet. 1985 Feb 23;1(8426):419-21. doi: 10.1016/s0140-6736(85)91145-6.
10
Human parvovirus B19 DNA in synovial fluid.滑液中的人细小病毒B19 DNA
Arthritis Rheum. 1988 Feb;31(2):279-81. doi: 10.1002/art.1780310218.
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