Nikkari S, Roivainen A, Hannonen P, Möttönen T, Luukkainen R, Yli-Jama T, Toivanen P
Department of Medical Microbiology, Turku University, Finland.
Ann Rheum Dis. 1995 Jul;54(7):597-600. doi: 10.1136/ard.54.7.597.
To determine whether parvovirus B19 (B19) persists in rheumatoid arthritis (RA).
Polymerase chain reaction (PCR) was used to detect parvovirus B19 genome in the synovial fluid cells or peripheral blood mononuclear cells from 61 patients with early RA; bone marrow from one patient was also studied. The synovium or synovial fluid cells from 28 patients with advanced RA, and synovial fluid cell samples from 18 patients with reactive arthritis (as controls) were studied. Two separate sets of primers and probe were used.
Parvovirus B19 specific gene sequences were detected in two patients with early arthritis fulfilling the criteria for RA.
Parvovirus B19 does not play a significant role in the aetiopathogenesis of RA. However, a few cases of a disease indistinguishable from RA may be triggered by parvovirus B19 infection.
确定细小病毒B19（B19）是否在类风湿关节炎（RA）中持续存在。
采用聚合酶链反应（PCR）检测61例早期RA患者滑膜液细胞或外周血单个核细胞中的细小病毒B19基因组；还对1例患者的骨髓进行了研究。对28例晚期RA患者的滑膜或滑膜液细胞以及18例反应性关节炎患者（作为对照）的滑膜液细胞样本进行了研究。使用了两组不同的引物和探针。
在两名符合RA标准的早期关节炎患者中检测到细小病毒B19特异性基因序列。
细小病毒B19在RA的发病机制中不发挥重要作用。然而，少数与RA难以区分的疾病可能由细小病毒B19感染引发。
