de Waard F, Kemmeren J M, van Ginkel L A, Stolker A A
Department of Epidemiology, Utrecht University, The Netherlands.
Br J Cancer. 1995 Sep;72(3):784-7. doi: 10.1038/bjc.1995.411.
In a cohort of women aged 40-64 at entry, 12 h urine samples were obtained at the beginning of a follow-up period of up to 15 years in which incident cases of lung cancer were registered as well as deaths from lung cancer. In this cohort a nested case-control study (n = 397) was carried out by measuring urinary cotinine. The method for quantitation of cotinine was sensitive enough to study lung cancer risk not only in active smokers but also in passive smokers. The results seem to indicate that cotinine estimations in single 12 h samples of urine are enough to predict lung cancer risk. Relative risk rose with increasing levels of nicotine intake already in the range associated with passive smoking. The smoking-related risk of adenocarcinoma was much less than that of other lung carcinomas.
在一组入组时年龄为40 - 64岁的女性中，在长达15年的随访期开始时采集了12小时尿液样本，在此期间记录了肺癌的发病病例以及肺癌死亡情况。在该队列中，通过测量尿可替宁开展了一项巢式病例对照研究（n = 397）。可替宁定量方法足够灵敏，不仅可以研究主动吸烟者的肺癌风险，还能研究被动吸烟者的肺癌风险。结果似乎表明，单次12小时尿液样本中的可替宁测定足以预测肺癌风险。在与被动吸烟相关的范围内，相对风险随着尼古丁摄入量的增加而上升。腺癌与吸烟相关的风险远低于其他肺癌。
