McCallion W A, Ardill J E, Bamford K B, Potts S R, Boston V E
Royal Belfast Hospital For Sick Children.
Gut. 1995 Jul;37(1):35-8. doi: 10.1136/gut.37.1.35.
Acute Helicobacter pylori associated gastritis causes achlorhydria, a powerful stimulus to gastrin secretion. If H pylori infection is acquired primarily in early childhood, then the degree of hypergastrinaemia in seropositive children should be age dependent. Anti-Helicobacter antibodies and fasting gastrin concentrations were measured in 439 children aged 4 to 13 years attending hospital for routine day case surgery not connected with any gastrointestinal disorder. Thirty per cent were seropositive for H pylori. There was an inverse relationship between the fasting gastrin concentration and age; the mean fasting gastrin in children aged 4-5 years, 155 ng/l, was significantly higher than that seen in children aged 12-13 years, 90 ng/l. The more noticeable hypergastrinaemia seen in young children with H pylori associated gastritis may reflect achlorhydria associated with acute H pylori infection and suggests that this is primarily acquired in early childhood.
急性幽门螺杆菌相关性胃炎会导致胃酸缺乏，这是胃泌素分泌的强大刺激因素。如果幽门螺杆菌感染主要在儿童早期获得，那么血清阳性儿童的高胃泌素血症程度应该与年龄相关。对439名4至13岁因常规日间手术入院且与任何胃肠道疾病无关的儿童测量了抗幽门螺杆菌抗体和空腹胃泌素浓度。30%的儿童幽门螺杆菌血清阳性。空腹胃泌素浓度与年龄呈负相关；4至5岁儿童的平均空腹胃泌素为155 ng/l，显著高于12至13岁儿童的90 ng/l。在患有幽门螺杆菌相关性胃炎的幼儿中更明显的高胃泌素血症可能反映了与急性幽门螺杆菌感染相关的胃酸缺乏，并表明这种感染主要在儿童早期获得。
