结肠憩室病中胶原蛋白的交联增加。
Cross linking of collagen is increased in colonic diverticulosis.
作者信息
Wess L, Eastwood M A, Wess T J, Busuttil A, Miller A
机构信息
Department of Biochemistry, University of Edinburgh Medical School.
出版信息
Gut. 1995 Jul;37(1):91-4. doi: 10.1136/gut.37.1.91.
Development of colonic diverticulosis is a function of age and declining colonic wall mechanical strength. The latter is partly a consequence of changes in the collagen structure. Collagen from unaffected human colons (n = 20, age range 20-80 years) and those with colonic diverticulosis (n = 5, age range 67-80 years) were obtained at necropsy. The total collagen content was measured as the hydroxyproline content and cross linkage by collagen solubility in weak acid was studied. The colonic total collagen content was constant with age (mean (SD) 15.8 (0.3) mg/100 mg wet weight of tissue). The acid solubility of the collagen, however, increased after the age of 40 years: at over 60 years, colonic diverticulosis was associated with an increased acid solubility ratio compared with values in unaffected colons (15.3 (0.2); compared with 9.2 (0.2), p < 0.001). The cross linking of colonic collagen increases with age. These changes seem to be a factor in the aetiology of colonic diverticulosis.
结肠憩室病的发生是年龄和结肠壁机械强度下降的函数。后者部分是胶原蛋白结构变化的结果。在尸检时获取了来自未受影响的人类结肠（n = 20，年龄范围20 - 80岁）和患有结肠憩室病的结肠（n = 5，年龄范围67 - 80岁）的胶原蛋白。将总胶原蛋白含量测定为羟脯氨酸含量，并研究了胶原蛋白在弱酸中的交联情况。结肠总胶原蛋白含量随年龄保持恒定（平均（标准差）15.8（0.3）mg/100mg组织湿重）。然而，胶原蛋白的酸溶解度在40岁以后增加：在60岁以上，与未受影响的结肠相比，结肠憩室病与酸溶解度比值增加相关（15.3（0.2）；与9.2（0.2）相比，p < 0.001）。结肠胶原蛋白的交联随年龄增加。这些变化似乎是结肠憩室病病因学中的一个因素。
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