Rosling B, Nyman S, Lindhe J
J Clin Periodontol. 1976 Feb;3(1):38-53. doi: 10.1111/j.1600-051x.1976.tb01849.x.
A clinical trial was undertaken to test the hypothesis that periodontitis can be cured and that bone regeneration occurs in infrabony pockets in patients maintained on an optimal standard of oral hygiene. The material comprised 24 patients with advanced periodontal disease. After an initial examination, the patients were randomly distributed into one test group and one control group. All the patients were given instruction and practice in a proper oral hygiene technique, and then subjected to periodontal surgery using the modified Widman flap procedure. Following treatment, during a 2-year period the patients of the test group were recalled once every second week for professional tooth cleaning. The control patients were recalled once every 12 months for prophylaxis. The results showed that all osseous defects of the patients of the test group were refilled with bone. The control patients, on the other hand, could not maintain a high standard of oral hygiene, and exhibited a progressive deterioration of the periodontal tissues during the postsurgical observation time.
进行了一项临床试验，以检验以下假设：在保持最佳口腔卫生标准的患者中，牙周炎可以治愈，并且骨下袋中会发生骨再生。研究材料包括24名患有晚期牙周病的患者。经过初步检查后，患者被随机分为一个试验组和一个对照组。所有患者都接受了正确口腔卫生技术的指导和练习，然后采用改良Widman瓣手术进行牙周手术。治疗后，在两年期间，试验组患者每两周被召回进行一次专业牙齿清洁。对照组患者每12个月被召回进行一次预防治疗。结果显示，试验组患者的所有骨缺损均被骨填充。另一方面，对照组患者无法保持高标准的口腔卫生，并且在术后观察期间牙周组织出现进行性恶化。
