Ramirez-Peña Ana Maria, Sánchez-Pérez Arturo, Campos-Aranda Matilde, Hidalgo-Tallón Francisco Javier
Ministerio de Educación Superior Ciencia y Tecnología República Dominicana, Santo Domingo de Guzmán 10204, Dominican Republic.
Clínica Odontológica Universitaria, Hospital Morales Meseguer, Marques de los Vélez, 2° Floor, University of Murcia, 30008 Murcia, Spain.
J Clin Med. 2022 May 23;11(10):2946. doi: 10.3390/jcm11102946.
The purpose of this article was to assess the effectiveness of ozone therapy as an adjunct to mechanical therapy in periodontitis patients. Thirty-two patients diagnosed with generalized periodontitis were selected, with a total of 655 teeth examined. Each patient’s mouth was divided into four quadrants (the split-mouth model) to be randomly treated with four sessions of gaseous ozone or air. The following clinical variables were recorded: the gingival index, the periodontal clinical attachment loss, the Miller’s mobility index and the clinical improvements, as assessed through the visual analog scale (VAS). In addition, the microorganisms were qualitatively compared. After four weeks of treatment, the teeth of the ozone-treated quadrants showed statistically significant reductions in the gingival index and an improvement in the clinical attachment (p < 0.0001). The same treatment also significantly improved mobility by between 70% and 86% compared to the control group (p < 0.0001). Statistically significant differences were also recorded for the VAS (p < 0.0001). In the qualitative study of the subgingival flora, significant differences were observed (p < 0.0001). The overall results of this trial support the view that ozone treatment is effective and well tolerated in cases of generalized chronic periodontitis.
本文的目的是评估臭氧疗法作为机械疗法辅助手段治疗牙周炎患者的有效性。选取了32例被诊断为广泛性牙周炎的患者，共检查655颗牙齿。将每位患者的口腔分为四个象限（分口模型），随机接受四疗程的气态臭氧或空气治疗。记录以下临床变量：牙龈指数、牙周临床附着丧失、米勒松动指数以及通过视觉模拟量表（VAS）评估的临床改善情况。此外，还对微生物进行了定性比较。治疗四周后，接受臭氧治疗象限的牙齿牙龈指数在统计学上显著降低，临床附着情况得到改善（p < 0.0001）。与对照组相比，相同治疗还使松动度显著改善了70%至86%（p < 0.0001）。VAS也记录到了统计学上的显著差异（p < 0.0001）。在龈下菌群的定性研究中，观察到了显著差异（p < 0.0001）。该试验的总体结果支持以下观点，即臭氧治疗在广泛性慢性牙周炎病例中有效且耐受性良好。
