Huber T S, Harward T R, Flynn T C, Albright J L, Seeger J M
Department of Surgery, University of Florida College of Medicine, Gainesville 32610-0286, USA.
J Vasc Surg. 1995 Sep;22(3):287-93; discussion 293-4. doi: 10.1016/s0741-5214(95)70143-5.
This study was designed to test the hypothesis that cardiac complications (myocardial infarction, congestive heart failure, fatal arrhythmias) are no longer the leading cause of death after elective aortic reconstructions.
The medical records of all elective infrarenal aortic reconstructions performed between January 1982 and June 1994 were retrospectively reviewed. All perioperative deaths were analyzed to determine the cause of death and were compared with a subset of 266 survivors to identify any associated preoperative or intraoperative factors.
Seven hundred twenty-two aortic reconstructions were performed for aneurysmal or occlusive disease, and there were 44 deaths (overall mortality rate of 6.1%). The mortality rate after aortic reconstruction alone was 4.9% and increased with the addition of renal (8.9%, p = 0.16) or lower extremity vascular procedures (15.8%, p = 0.01). Multisystem organ failure (MSOF) was the cause of death in 56.8%, of the patients (3.5% overall mortality rate) followed by cardiac events in 25% (1.5% overall mortality rate). Visceral organ dysfunction was the most common cause of MSOF leading to death in 14 patients (56.0%), and postoperative pneumonia was responsible for the fatal MSOF in nine patients (36.0%). Patient age, history of myocardial infarction/congestive heart failure, ejection fraction less than 50%, duration of operative time, and performance of additional procedures were associated with increased operative mortality rates by multivariate analysis.
MSOF, predominantly from visceral organ dysfunction, was the leading cause of death after elective infrarenal aortic reconstruction. The risk of MSOF and operative death increases with the complexity of the procedure and the number of comorbid conditions.
本研究旨在验证以下假设,即心脏并发症(心肌梗死、充血性心力衰竭、致命性心律失常)不再是择期主动脉重建术后的主要死亡原因。
回顾性分析1982年1月至1994年6月间所有择期肾下腹主动脉重建手术的病历。对所有围手术期死亡病例进行分析以确定死因,并与266名幸存者的子集进行比较,以确定任何相关的术前或术中因素。
因动脉瘤或闭塞性疾病进行了722例主动脉重建手术,其中44例死亡(总死亡率为6.1%)。单纯主动脉重建后的死亡率为4.9%,随着肾脏(8.9%,p = 0.16)或下肢血管手术的增加而升高(15.8%,p = 0.01)。多系统器官衰竭(MSOF)是56.8%患者的死亡原因(总死亡率为3.5%),其次是心脏事件,占25%(总死亡率为1.5%)。内脏器官功能障碍是导致14例患者(56.0%)死亡的MSOF的最常见原因,术后肺炎导致9例患者(36.0%)出现致命性MSOF。多因素分析显示,患者年龄、心肌梗死/充血性心力衰竭病史、射血分数低于50%、手术时间以及额外手术的实施与手术死亡率增加相关。
主要由内脏器官功能障碍引起的MSOF是择期肾下腹主动脉重建术后的主要死亡原因。MSOF和手术死亡的风险随着手术复杂性和合并症数量的增加而增加。