Yi Y, Zhong G, Brunham R C
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
Infect Immun. 1993 Mar;61(3):1117-20. doi: 10.1128/iai.61.3.1117-1120.1993.
B-cell peptide epitopes in chlamydial heat shock protein 60 (hsp60) were elucidated with antisera from 13 rabbits immunized with Chlamydia trachomatis serovars B, C, and L2 and antisera from eight women with C. trachomatis-associated ectopic pregnancies. Thirteen major epitopes were identified with the human sera, 10 of which were also observed with rabbit antisera. Seven of the 13 epitopes recognized by human antisera exhibited cross-reactive antibody binding to homologous peptide sequences in human hsp60. Self-reactive B-cell immunity to hsp60 may contribute to chlamydial disease pathogenesis.
利用沙眼衣原体血清型B、C和L2免疫的13只兔子的抗血清以及8名患有沙眼衣原体相关异位妊娠的女性的抗血清，阐明了衣原体热休克蛋白60（hsp60）中的B细胞肽表位。用人血清鉴定出13个主要表位，其中10个也在兔抗血清中观察到。人抗血清识别的13个表位中有7个表现出与人类hsp60中的同源肽序列交叉反应性抗体结合。对hsp60的自身反应性B细胞免疫可能有助于衣原体疾病的发病机制。
