沙眼衣原体热休克蛋白60中的连续B细胞表位。
Continuous B-cell epitopes in Chlamydia trachomatis heat shock protein 60.
作者信息
Yi Y, Zhong G, Brunham R C
机构信息
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
出版信息
Infect Immun. 1993 Mar;61(3):1117-20. doi: 10.1128/iai.61.3.1117-1120.1993.
Abstract
B-cell peptide epitopes in chlamydial heat shock protein 60 (hsp60) were elucidated with antisera from 13 rabbits immunized with Chlamydia trachomatis serovars B, C, and L2 and antisera from eight women with C. trachomatis-associated ectopic pregnancies. Thirteen major epitopes were identified with the human sera, 10 of which were also observed with rabbit antisera. Seven of the 13 epitopes recognized by human antisera exhibited cross-reactive antibody binding to homologous peptide sequences in human hsp60. Self-reactive B-cell immunity to hsp60 may contribute to chlamydial disease pathogenesis.
摘要
利用沙眼衣原体血清型B、C和L2免疫的13只兔子的抗血清以及8名患有沙眼衣原体相关异位妊娠的女性的抗血清，阐明了衣原体热休克蛋白60（hsp60）中的B细胞肽表位。用人血清鉴定出13个主要表位，其中10个也在兔抗血清中观察到。人抗血清识别的13个表位中有7个表现出与人类hsp60中的同源肽序列交叉反应性抗体结合。对hsp60的自身反应性B细胞免疫可能有助于衣原体疾病的发病机制。
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本文引用的文献
1
Chlamydia trachomatis: its role in tubal infertility.沙眼衣原体：其在输卵管性不孕中的作用。
J Infect Dis. 1985 Dec;152(6):1275-82. doi: 10.1093/infdis/152.6.1275.
2
Chlamydial disease pathogenesis. Ocular hypersensitivity elicited by a genus-specific 57-kD protein.衣原体病发病机制。由一种属特异性57-kD蛋白引发的眼部超敏反应。
J Exp Med. 1989 Mar 1;169(3):663-75. doi: 10.1084/jem.169.3.663.
3
Stress proteins, infection, and immune surveillance.应激蛋白、感染与免疫监视
Cell. 1989 Oct 6;59(1):5-8. doi: 10.1016/0092-8674(89)90861-1.
4
Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein.衣原体疾病发病机制。57-kD衣原体超敏抗原是一种应激反应蛋白。
J Exp Med. 1989 Oct 1;170(4):1271-83. doi: 10.1084/jem.170.4.1271.
5
Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen.一种与细菌和植物伴侣蛋白以及65千道尔顿分枝杆菌抗原同源的人类线粒体蛋白的一级结构。
Mol Cell Biol. 1989 May;9(5):2279-83. doi: 10.1128/mcb.9.5.2279-2283.1989.
6
Strategies for epitope analysis using peptide synthesis.使用肽合成进行表位分析的策略。
J Immunol Methods. 1987 Sep 24;102(2):259-74. doi: 10.1016/0022-1759(87)90085-8.
7
Differential human serologic response to two 60,000 molecular weight Chlamydia trachomatis antigens.人类对两种60,000分子量沙眼衣原体抗原的不同血清学反应。
J Infect Dis. 1990 Oct;162(4):922-7. doi: 10.1093/infdis/162.4.922.
8
The Chlamydia trachomatis hyp operon is homologous to the groE stress response operon of Escherichia coli.沙眼衣原体的hyp操纵子与大肠杆菌的groE应激反应操纵子同源。
Infect Immun. 1990 Aug;58(8):2701-5. doi: 10.1128/iai.58.8.2701-2705.1990.
9
Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein.沙眼衣原体热休克蛋白60基因的克隆、序列分析及其蛋白的免疫反应性
Infect Immun. 1991 Jan;59(1):79-90. doi: 10.1128/iai.59.1.79-90.1991.
10
The antibody repertoire to proteins of Mycobacterium leprae. Genetic influences at the antigen and epitope level.
J Immunol. 1991 Sep 15;147(6):1947-53.
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