Asmawi M Z, Kankaanranta H, Moilanen E, Vapaatalo H
Department of Biomedical Sciences, University of Tampere, Finland.
J Pharm Pharmacol. 1993 Jun;45(6):581-4. doi: 10.1111/j.2042-7158.1993.tb05605.x.
Emblica officinalis Gaertn, a tree growing in subtropical and tropical parts of China, India, Indonesia and the Malay Peninsula, has been used for anti-inflammatory and antipyretic treatments of rural populations in these areas. In the present study, we examined the effects of Emblica officinalis extracts on carrageenan- and dextran-induced rat hind paw oedema. Anti-inflammatory activity was found in the water fraction of methanol extract of the plant leaves. The effects of the same fraction were tested on the synthesis of mediators of inflammation such as leukotriene B4 (LTB4), platelet-activating factor (PAF) and thromboxane B2 (TXB2), and on LTB4- and N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP)-induced migration of human polymorphonuclear leucocytes (PMNs) in-vitro. The water fraction of the methanol extract inhibited migration of human PMNs in relatively low concentrations. It did not inhibit LTB4 or PAF synthesis in human PMNs or TXB2 synthesis in human platelets during clotting, suggesting that the mechanism of the anti-inflammatory action found in the rat paw model does not involve inhibition of the synthesis of the measured lipid mediators.
余甘子，一种生长在中国、印度、印度尼西亚和马来半岛亚热带和热带地区的树木，已被这些地区的农村人口用于抗炎和解热治疗。在本研究中，我们研究了余甘子提取物对角叉菜胶和右旋糖酐诱导的大鼠后爪水肿的影响。在该植物叶子甲醇提取物的水相中发现了抗炎活性。测试了同一部分对炎症介质如白三烯B4（LTB4）、血小板活化因子（PAF）和血栓素B2（TXB2）合成的影响，以及对LTB4和N-甲酰-L-蛋氨酰-L-亮氨酰-L-苯丙氨酸（FMLP）诱导的人多形核白细胞（PMN）体外迁移的影响。甲醇提取物的水相在相对低浓度下抑制人PMN的迁移。它在凝血过程中不抑制人PMN中LTB4或PAF的合成或人血小板中TXB2的合成，这表明在大鼠爪模型中发现的抗炎作用机制不涉及对所测脂质介质合成的抑制。
