用Marshal及其有效成分克百威处理的培养人淋巴细胞中的染色体畸变。

Chromosomal aberrations in cultured human lymphocytes treated with Marshal and its effective ingredient Carbosulfan.

作者信息

Topaktaş M, Rencüzoğullar E

机构信息

Cukurova University, Faculty of Arts and Sciences, Department of Biology, Adana, Turkey.

出版信息

Mutat Res. 1993 Oct;319(2):103-11. doi: 10.1016/0165-1218(93)90068-o.

DOI:10.1016/0165-1218(93)90068-o

PMID:7692285

Abstract

The aim of this study was to investigate the ability of Marshal (insecticide/nematocide) and its effective ingredient Carbosulfan to induce chromosomal aberrations (CA) and other chromosomal abnormalities in human peripheral lymphocytes. Carbosulfan induced the formation of CA at all concentrations (10(-6), 5 x 10(-6), 10(-5), 5 x 10(-5) v/v) and treatment times. Marshal significantly induced the formation of CA at the two highest concentrations (10(-5) and 5 x 10(-5) v/v) at all treatment times. The extent of damage was greatest with Carbosulfan.

摘要

本研究的目的是调查Marshal（杀虫剂/杀线虫剂）及其有效成分丁硫克百威诱导人外周血淋巴细胞染色体畸变（CA）和其他染色体异常的能力。丁硫克百威在所有浓度（10⁻⁶、5×10⁻⁶、10⁻⁵、5×10⁻⁵ v/v）和处理时间下均诱导了CA的形成。Marshal在所有处理时间下，在两个最高浓度（10⁻⁵和5×10⁻⁵ v/v）时均显著诱导了CA的形成。丁硫克百威造成的损伤程度最大。