博来霉素可增加携带转座子Tn5的大肠杆菌对阿米卡星和链霉素的耐药性。
Bleomycin increases amikacin and streptomycin resistance in Escherichia coli harboring transposon Tn5.
作者信息
Blazquez J, Martinez J L, Baquero F
机构信息
Servicio de Microbiología, Hospital Ramón y Cajal, Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 1993 Sep;37(9):1982-5. doi: 10.1128/AAC.37.9.1982.
Abstract
The antitumor antibiotic bleomycin acts as a transcriptional inducer of the neo-ble-str operon of the transposon Tn5, increasing the resistance level to streptomycin and amikacin in Tn5-containing Escherichia coli. The mechanism may involve a recA-independent induction mediated by DNA damage.
摘要
抗肿瘤抗生素博来霉素作为转座子Tn5的新博来霉素抗性操纵子（neo-ble-str operon）的转录诱导剂，可提高含Tn5的大肠杆菌对链霉素和阿米卡星的抗性水平。其机制可能涉及由DNA损伤介导的不依赖RecA的诱导作用。
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