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齐多夫定立即治疗可保护感染猿猴免疫缺陷病毒的新生猕猴免于艾滋病的快速发作。

Immediate zidovudine treatment protects simian immunodeficiency virus-infected newborn macaques against rapid onset of AIDS.

作者信息

Van Rompay K K, Otsyula M G, Marthas M L, Miller C J, McChesney M B, Pedersen N C

机构信息

California Regional Primate Research Center, University of California, Davis 95616.

出版信息

Antimicrob Agents Chemother. 1995 Jan;39(1):125-31. doi: 10.1128/AAC.39.1.125.

DOI:10.1128/AAC.39.1.125
PMID:7695293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC162497/
Abstract

Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a practical animal model of pediatric AIDS. Intravenous inoculation of rhesus newborns with uncloned SIVmac resulted in a high virus load, no antiviral immune responses, severe immunodeficiency, and a high mortality rate within 3 months. In contrast, immediate oral zidovudine (AZT) treatment of SIV-inoculated rhesus newborns either prevented infection or resulted in reduced virus load, enhanced antiviral immune responses, a low frequency of AZT-resistant virus isolates, and delayed disease progression with negligible toxicity. These results suggest that early chronic AZT treatment of human immunodeficiency virus-exposed newborns may have benefits that outweigh its potential side effects.

摘要

新生恒河猴感染猿猴免疫缺陷病毒（SIV）是儿童艾滋病的一种实用动物模型。给恒河猴新生儿静脉接种未克隆的SIVmac会导致高病毒载量、无抗病毒免疫反应、严重免疫缺陷以及在3个月内出现高死亡率。相比之下，对接种SIV的恒河猴新生儿立即进行口服齐多夫定（AZT）治疗，要么可预防感染，要么可降低病毒载量、增强抗病毒免疫反应、降低AZT耐药病毒分离株的出现频率，并延缓疾病进展，且毒性可忽略不计。这些结果表明，对暴露于人类免疫缺陷病毒的新生儿进行早期长期AZT治疗可能利大于弊。

相似文献

1
Immediate zidovudine treatment protects simian immunodeficiency virus-infected newborn macaques against rapid onset of AIDS.齐多夫定立即治疗可保护感染猿猴免疫缺陷病毒的新生猕猴免于艾滋病的快速发作。
Antimicrob Agents Chemother. 1995 Jan;39(1):125-31. doi: 10.1128/AAC.39.1.125.
2
Viral factors determine progression to AIDS in simian immunodeficiency virus-infected newborn rhesus macaques.病毒因素决定了感染猿猴免疫缺陷病毒的新生恒河猴向艾滋病的进展。
J Virol. 1995 Jul;69(7):4198-205. doi: 10.1128/JVI.69.7.4198-4205.1995.
3
Vaccination of pregnant macaques protects newborns against mucosal simian immunodeficiency virus infection.对怀孕猕猴进行疫苗接种可保护新生猕猴免受黏膜型猿猴免疫缺陷病毒感染。
J Infect Dis. 1996 Jun;173(6):1327-35. doi: 10.1093/infdis/173.6.1327.
4
Simian immunodeficiency virus (SIV) infection of infant rhesus macaques as a model to test antiretroviral drug prophylaxis and therapy: oral 3'-azido-3'-deoxythymidine prevents SIV infection.以恒河猴婴儿感染猿猴免疫缺陷病毒（SIV）作为模型来测试抗逆转录病毒药物预防和治疗效果：口服3'-叠氮-3'-脱氧胸苷可预防SIV感染。
Antimicrob Agents Chemother. 1992 Nov;36(11):2381-6. doi: 10.1128/AAC.36.11.2381.
5
Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.给予9-[2-(膦酰甲氧基)丙基]腺嘌呤（PMPA）预防恒河猴围产期猿猴免疫缺陷病毒感染。
AIDS Res Hum Retroviruses. 1998 Jun 10;14(9):761-73. doi: 10.1089/aid.1998.14.761.
6
Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.新生恒河猴的被动免疫可预防口腔感染猿猴免疫缺陷病毒。
J Infect Dis. 1998 May;177(5):1247-59. doi: 10.1086/515270.
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Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection.两剂替诺福韦酯可保护新生猕猴免受口服猿猴免疫缺陷病毒感染。
AIDS. 1998 Jun 18;12(9):F79-83. doi: 10.1097/00002030-199809000-00001.
8
Early intrathecal events in rhesus macaques (Macaca mulatta) infected with pathogenic or nonpathogenic molecular clones of simian immunodeficiency virus.感染猿猴免疫缺陷病毒致病性或非致病性分子克隆的恒河猴（猕猴）的早期鞘内事件。
Lab Invest. 1995 May;72(5):547-58.
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Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus.齐多夫定治疗可延长围产期感染猴免疫缺陷病毒的恒河猴的生存期，并降低其中枢神经系统中的病毒载量。
J Infect Dis. 1995 Jul;172(1):59-69. doi: 10.1093/infdis/172.1.59.
10
Comparison of the efficacy of AZT and PMEA treatment against acute SIVmne infection in macaques.
J Med Primatol. 1994 Feb-May;23(2-3):175-83. doi: 10.1111/j.1600-0684.1994.tb00119.x.

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Italian consensus statement on paediatric HIV infection.意大利关于儿科 HIV 感染的共识声明。
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Paediatr Child Health. 2004 Jul;9(6):409-28. doi: 10.1093/pch/9.6.409.
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本文引用的文献

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Standardized peripheral blood mononuclear cell culture assay for determination of drug susceptibilities of clinical human immunodeficiency virus type 1 isolates. The RV-43 Study Group, the AIDS Clinical Trials Group Virology Committee Resistance Working Group.用于测定临床1型人类免疫缺陷病毒分离株药物敏感性的标准化外周血单核细胞培养试验。RV - 43研究组，艾滋病临床试验组病毒学委员会耐药性工作组。
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Administration of zidovudine during primary HIV-1 infection may be associated with a less vigorous immune response.在原发性HIV-1感染期间给予齐多夫定可能与免疫反应不那么强烈有关。
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Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus.对出生时暴露于人类免疫缺陷病毒的婴儿给予齐多夫定的I期评估。
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High-level resistance to zidovudine but not to zalcitabine or didanosine in human immunodeficiency virus from children receiving antiretroviral therapy.接受抗逆转录病毒治疗的儿童体内的人类免疫缺陷病毒对齐多夫定产生高水平耐药，但对扎西他滨或去羟肌苷未产生耐药。
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The pharmacokinetics and safety of zidovudine in the third trimester of pregnancy for women infected with human immunodeficiency virus and their infants: phase I acquired immunodeficiency syndrome clinical trials group study (protocol 082). Zidovudine Collaborative Working Group.齐多夫定在妊娠晚期感染人类免疫缺陷病毒的孕妇及其婴儿中的药代动力学和安全性：I期获得性免疫缺陷综合征临床试验组研究（方案082）。齐多夫定协作工作组
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Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.齐多夫定治疗降低母婴1型人类免疫缺陷病毒传播。儿童艾滋病临床试验组方案076研究小组。
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