肾移植受者中的T淋巴细胞。
T lymphocytes in kidney allograft recipients.
作者信息
Tursz T, Fournier C, Kreis H, Crosnier J, Bach J F
出版信息
Br Med J. 1976 Apr 3;1(6013):799-801. doi: 10.1136/bmj.1.6013.799.
The spontaneous sheep erythrocyte (E) rosette test was used on 340 occasions to measure T cell levels in 28 renal allograft recipients. The E rosette counts were reduced by high-dose steroids but usually returned towards normal under maintenance treatment with azathioprine and low-dose prednisone. Unexpectedly, rejection crises were more often associated with a decrease in E rosettes before steroid treatment (12 cases) than with an increase in E rosettes (5 cases). Our results show the need for caution in using the E rosette test and more generally B and T cell markers for monitoring anti-graft immunity in renal allograft recipients.
对28例肾移植受者进行了340次自发绵羊红细胞（E）玫瑰花结试验，以检测T细胞水平。高剂量类固醇会使E玫瑰花结计数降低，但在使用硫唑嘌呤和低剂量泼尼松维持治疗时，计数通常会恢复正常。出乎意料的是，排斥反应危机在类固醇治疗前E玫瑰花结减少的情况（12例）比E玫瑰花结增加的情况（5例）更常见。我们的结果表明，在肾移植受者中使用E玫瑰花结试验以及更广泛地使用B和T细胞标志物来监测抗移植物免疫时需要谨慎。
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