1型人类免疫缺陷病毒感染患者中诱导合胞体病毒和非诱导合胞体病毒的定量分析。
Quantitative analysis of syncytium-inducing and non-syncytium-inducing virus in patients infected with human immunodeficiency virus type 1.
作者信息
Shafer R W, Aguiniga E, Merigan T C
机构信息
Center for AIDS Research, Stanford University School of Medicine, California 94305.
出版信息
J Clin Microbiol. 1995 Jan;33(1):212-4. doi: 10.1128/jcm.33.1.212-214.1995.
Abstract
Among 75 consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients with moderate and advanced immunosuppression, those harboring syncytium-inducing (SI) HIV-1 had a lower CD(4+)-cell count (145 versus 278 cells per microliter, P < 0.001) and 10-fold-higher virus titers than patients with non-SI HIV-1 (398 versus 39 infectious units per 10(6) CD4+ lymphocytes; P < 0.001). In patients with SI virus, the mean titer of SI virus, determined with a quantitative MT-2 cell assay, was 135 SI infectious units per 10(6) CD4+ lymphocytes. Virus titer correlated inversely with CD(4+)-cell count in patients with SI (r = -0.67) but not non-SI (r = -0.29) virus.
摘要
在75例连续感染1型人类免疫缺陷病毒（HIV-1）且免疫抑制程度为中度和重度的患者中，携带合胞体诱导型（SI）HIV-1的患者的CD4+细胞计数较低（每微升145个细胞对278个细胞，P<0.001），病毒滴度比非SI HIV-1患者高10倍（每10^6个CD4+淋巴细胞中398个对39个感染单位；P<0.001）。在携带SI病毒的患者中，用定量MT-2细胞试验测定的SI病毒平均滴度为每10^6个CD4+淋巴细胞135个SI感染单位。在携带SI病毒的患者中，病毒滴度与CD4+细胞计数呈负相关（r=-0.67），但在携带非SI病毒的患者中无此相关性（r=-0.29）。
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本文引用的文献
1
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J Acquir Immune Defic Syndr (1988). 1993 Mar;6(3):237-40.
2
Use of virologic assays for detection of human immunodeficiency virus in clinical trials: recommendations of the AIDS Clinical Trials Group Virology Committee.在临床试验中使用病毒学检测方法检测人类免疫缺陷病毒：艾滋病临床试验组病毒学委员会的建议
J Clin Microbiol. 1993 Oct;31(10):2557-64. doi: 10.1128/jcm.31.10.2557-2564.1993.
3
Enhanced expression of human immunodeficiency virus type 1 correlates with development of AIDS.人类免疫缺陷病毒1型的表达增强与艾滋病的发展相关。
Virology. 1993 Oct;196(2):586-95. doi: 10.1006/viro.1993.1514.
4
Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.HIV-1 合胞体诱导表型对 CD4+ 细胞耗竭率及进展至艾滋病的预后价值。
Ann Intern Med. 1993 May 1;118(9):681-8. doi: 10.7326/0003-4819-118-9-199305010-00004.
5
Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals.在1型人类免疫缺陷病毒感染个体中，病毒载量增加和细胞病变效应在时间上与CD4 + T淋巴细胞减少及临床进展相关。
J Virol. 1993 Apr;67(4):1772-7. doi: 10.1128/JVI.67.4.1772-1777.1993.
6
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.人类外周血中HIV-1的储存库是一种维持CD4表达的T细胞。
Science. 1989 Jul 21;245(4915):305-8. doi: 10.1126/science.2665081.
7
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N Engl J Med. 1989 Dec 14;321(24):1621-5. doi: 10.1056/NEJM198912143212401.
8
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J Virol. 1989 May;63(5):2118-25. doi: 10.1128/JVI.63.5.2118-2125.1989.
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N Engl J Med. 1989 Dec 14;321(24):1626-31. doi: 10.1056/NEJM198912143212402.
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J Virol. 1992 Mar;66(3):1354-60. doi: 10.1128/JVI.66.3.1354-1360.1992.
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