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1
Quantitative analysis of syncytium-inducing and non-syncytium-inducing virus in patients infected with human immunodeficiency virus type 1.1型人类免疫缺陷病毒感染患者中诱导合胞体病毒和非诱导合胞体病毒的定量分析。
J Clin Microbiol. 1995 Jan;33(1):212-4. doi: 10.1128/jcm.33.1.212-214.1995.
2
Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection.1型人类免疫缺陷病毒感染过程中细胞负荷变化、病毒表型演变与病毒群体克隆组成之间的关系。
J Infect Dis. 1996 Feb;173(2):349-54. doi: 10.1093/infdis/173.2.349.
3
Infectious virus titer, replicative and syncytium-inducing capacity of human immunodeficiency virus type 1.
J Med Virol. 1995 Jan;45(1):78-81. doi: 10.1002/jmv.1890450115.
4
Differential coreceptor expression allows for independent evolution of non-syncytium-inducing and syncytium-inducing HIV-1.不同的共受体表达使得非合胞体诱导型和合胞体诱导型HIV-1能够独立进化。
J Clin Invest. 2000 Oct;106(8):1039-52. doi: 10.1172/JCI7953.
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Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.HIV-1 合胞体诱导表型对 CD4+ 细胞耗竭率及进展至艾滋病的预后价值。
Ann Intern Med. 1993 May 1;118(9):681-8. doi: 10.7326/0003-4819-118-9-199305010-00004.
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Syncytium induction in primary CD4+ T-cell lines from normal donors by human immunodeficiency virus type 1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells.在MT-2细胞中具有非合胞体诱导基因型和表型的1型人类免疫缺陷病毒分离株对来自正常供体的原代CD4 + T细胞系进行合胞体诱导。
J Virol. 1995 Nov;69(11):7099-105. doi: 10.1128/JVI.69.11.7099-7105.1995.
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The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression.
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Resistance against syncytium-inducing human immunodeficiency virus type 1 (HIV-1) in selected CD4(+) T cells from an HIV-1-infected nonprogressor: evidence of a novel pathway of resistance mediated by a soluble factor(s) that acts after virus entry.来自一名HIV-1感染非进展者的部分CD4(+) T细胞对合胞体诱导性人类免疫缺陷病毒1型（HIV-1）的抗性：由病毒进入后起作用的一种或多种可溶性因子介导的新型抗性途径的证据。
J Virol. 1999 Sep;73(9):7891-8. doi: 10.1128/JVI.73.9.7891-7898.1999.
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Broader tropism and higher cytopathicity for CD4+ T cells of a syncytium-inducing compared to a non-syncytium-inducing HIV-1 isolate as a mechanism for accelerated CD4+ T cell decline in vivo.与非合胞体诱导型HIV-1分离株相比，合胞体诱导型HIV-1分离株对CD4+ T细胞具有更广泛的嗜性和更高的细胞病变效应，这是体内CD4+ T细胞加速减少的一种机制。
Virology. 1996 May 1;219(1):87-95. doi: 10.1006/viro.1996.0225.
10
Effect of the HIV-1 syncytium-inducing phenotype on disease stage in vertically-infected children.HIV-1合胞体诱导表型对垂直感染儿童疾病阶段的影响。
J Med Virol. 1998 May;55(1):56-63. doi: 10.1002/(sici)1096-9071(199805)55:1<56::aid-jmv10>3.0.co;2-y.

本文引用的文献

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Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells.外周血单个核细胞和分离的CD4+ T细胞中HIV-1前病毒载量的定量与比较。
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Use of virologic assays for detection of human immunodeficiency virus in clinical trials: recommendations of the AIDS Clinical Trials Group Virology Committee.在临床试验中使用病毒学检测方法检测人类免疫缺陷病毒：艾滋病临床试验组病毒学委员会的建议
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Enhanced expression of human immunodeficiency virus type 1 correlates with development of AIDS.人类免疫缺陷病毒1型的表达增强与艾滋病的发展相关。
Virology. 1993 Oct;196(2):586-95. doi: 10.1006/viro.1993.1514.
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Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.HIV-1 合胞体诱导表型对 CD4+ 细胞耗竭率及进展至艾滋病的预后价值。
Ann Intern Med. 1993 May 1;118(9):681-8. doi: 10.7326/0003-4819-118-9-199305010-00004.
5
Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals.在1型人类免疫缺陷病毒感染个体中，病毒载量增加和细胞病变效应在时间上与CD4 + T淋巴细胞减少及临床进展相关。
J Virol. 1993 Apr;67(4):1772-7. doi: 10.1128/JVI.67.4.1772-1777.1993.
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The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.人类外周血中HIV-1的储存库是一种维持CD4表达的T细胞。
Science. 1989 Jul 21;245(4915):305-8. doi: 10.1126/science.2665081.
7
Quantitation of human immunodeficiency virus type 1 in the blood of infected persons.1型人类免疫缺陷病毒在感染者血液中的定量分析。
N Engl J Med. 1989 Dec 14;321(24):1621-5. doi: 10.1056/NEJM198912143212401.
8
Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates.毒性人类免疫缺陷病毒（HIV）变异体在获得性免疫缺陷综合征发病机制中作用的证据：对连续HIV分离株的研究
J Virol. 1989 May;63(5):2118-25. doi: 10.1128/JVI.63.5.2118-2125.1989.
9
Plasma viremia in human immunodeficiency virus infection.人类免疫缺陷病毒感染中的血浆病毒血症。
N Engl J Med. 1989 Dec 14;321(24):1626-31. doi: 10.1056/NEJM198912143212402.
10
Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population.人类免疫缺陷病毒1型克隆在感染不同阶段的生物学表型：疾病进展与从嗜单核细胞病毒群体向嗜T细胞病毒群体的转变相关。
J Virol. 1992 Mar;66(3):1354-60. doi: 10.1128/JVI.66.3.1354-1360.1992.

1型人类免疫缺陷病毒感染患者中诱导合胞体病毒和非诱导合胞体病毒的定量分析。

Quantitative analysis of syncytium-inducing and non-syncytium-inducing virus in patients infected with human immunodeficiency virus type 1.

作者信息

Shafer R W, Aguiniga E, Merigan T C

机构信息

Center for AIDS Research, Stanford University School of Medicine, California 94305.

出版信息

J Clin Microbiol. 1995 Jan;33(1):212-4. doi: 10.1128/jcm.33.1.212-214.1995.

DOI:10.1128/jcm.33.1.212-214.1995
PMID:7699044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC227911/
Abstract

Among 75 consecutive human immunodeficiency virus type 1 (HIV-1)-infected patients with moderate and advanced immunosuppression, those harboring syncytium-inducing (SI) HIV-1 had a lower CD(4+)-cell count (145 versus 278 cells per microliter, P < 0.001) and 10-fold-higher virus titers than patients with non-SI HIV-1 (398 versus 39 infectious units per 10(6) CD4+ lymphocytes; P < 0.001). In patients with SI virus, the mean titer of SI virus, determined with a quantitative MT-2 cell assay, was 135 SI infectious units per 10(6) CD4+ lymphocytes. Virus titer correlated inversely with CD(4+)-cell count in patients with SI (r = -0.67) but not non-SI (r = -0.29) virus.

摘要

在75例连续感染1型人类免疫缺陷病毒（HIV-1）且免疫抑制程度为中度和重度的患者中，携带合胞体诱导型（SI）HIV-1的患者的CD4+细胞计数较低（每微升145个细胞对278个细胞，P<0.001），病毒滴度比非SI HIV-1患者高10倍（每10^6个CD4+淋巴细胞中398个对39个感染单位；P<0.001）。在携带SI病毒的患者中，用定量MT-2细胞试验测定的SI病毒平均滴度为每10^6个CD4+淋巴细胞135个SI感染单位。在携带SI病毒的患者中，病毒滴度与CD4+细胞计数呈负相关（r=-0.67），但在携带非SI病毒的患者中无此相关性（r=-0.29）。