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1
Separation of the mitogenic and antigenic responses to bacterial lipopolysaccharide.对细菌脂多糖的促有丝分裂反应和抗原反应的分离。
Immunology. 1976 Feb;30(2):241-8.
2
Effects of mitogens for mouse B lymphocytes on chicken lymphoid cells.小鼠B淋巴细胞有丝分裂原对鸡淋巴细胞的作用。
Immunology. 1975 Oct;29(4):697-707.
3
The effect of serum inhibitor on the antigenic and mitogenic responses to E. coli bacteria.血清抑制剂对大肠杆菌抗原性和促有丝分裂反应的影响。
J Immunol. 1976 Apr;116(4):1129-33.
4
Dissociation between mitogenicity and immunogenicity of TNP-lipopolysaccharide, a T-independent antigen.非胸腺依赖性抗原TNP-脂多糖的促有丝分裂活性与免疫原性之间的解离
J Exp Med. 1975 Jun 1;141(6):1453-8. doi: 10.1084/jem.141.6.1453.
5
Genetical control of B-cell responses. III. Requirement for functional mitogenicity of the antigen in thymus-independent specific responses.B细胞应答的遗传控制。III. 非胸腺依赖性特异性应答中抗原功能性促有丝分裂活性的需求。
J Exp Med. 1975 Apr 1;141(4):753-60.
6
LPS regulation of the immune response: separate mechanisms for murine B cell activation by lipid A (direct) and polysaccharide (macrophage-dependent) derived from Bacteroides LPS.脂多糖对免疫反应的调节：来自拟杆菌属脂多糖的脂质A（直接作用）和多糖（巨噬细胞依赖性）激活小鼠B细胞的不同机制。
J Immunol. 1984 Nov;133(5):2294-300.
7
Suppression and enhancement of the T cell-dependent production of antibody to SRBC in vitro by bacterial lipopolysaccharide.细菌脂多糖对体外T细胞依赖性抗绵羊红细胞抗体产生的抑制与增强作用。
J Immunol. 1975 Feb;114(2 pt 2):738-41.
8
The type-specific capsular carbohydrate of Hemophilus influenzae B is a potent mitogen for murine B lymphocytes.B型流感嗜血杆菌的型特异性荚膜多糖是鼠B淋巴细胞的一种有效促细胞分裂剂。
J Immunol. 1986 Nov 15;137(10):3130-4.
9
Immunologic properties of bacterial lipopolysaccharide (LPS). II. The unresponsiveness of C3H/HeJ Mouse spleen cells to LPS-induced mitogenesis is dependent on the method used to extract LPS.细菌脂多糖（LPS）的免疫学特性。II. C3H/HeJ小鼠脾细胞对LPS诱导的有丝分裂原反应不敏感取决于提取LPS所用的方法。
J Exp Med. 1975 Dec 1;142(6):1488-1508. doi: 10.1084/jem.142.6.1488.
10
Mechanism of thymus-independent immunocyte triggering. Mitogenic activation of B cells results in specific immune responses.非胸腺依赖性免疫细胞触发机制。B细胞的促有丝分裂激活导致特异性免疫反应。
J Exp Med. 1974 Jan 1;139(1):74-92. doi: 10.1084/jem.139.1.74.

引用本文的文献

1
Regulation of the immune response to bacterial lipopolysaccharide by adherent cells.黏附细胞对细菌脂多糖免疫应答的调节
Infect Immun. 1981 Aug;33(2):519-22. doi: 10.1128/iai.33.2.519-522.1981.
2
Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide.注射二硝基苯基化脂多糖的小鼠抗半抗原和抗载体反应的解离
Infect Immun. 1981 Jan;31(1):327-33. doi: 10.1128/iai.31.1.327-333.1981.
3
Suppression of the antibody response by phorbol esters in the mouse is due to an effect on the nylon wool adherent cell population.佛波酯对小鼠抗体反应的抑制作用是由于其对尼龙毛黏附细胞群体的影响。
Agents Actions. 1985 Sep;16(6):535-41. doi: 10.1007/BF01983659.
4
Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens.脂多糖佐剂活性的细胞需求。T淋巴细胞和巨噬细胞在体外对颗粒性抗原应答中的作用。
J Exp Med. 1979 Apr 1;149(4):793-807. doi: 10.1084/jem.149.4.793.
5
Depression of the antibody response in Pseudomonas aeruginosa-injected mice.铜绿假单胞菌注射小鼠体内抗体反应的抑制
Infect Immun. 1979 Apr;24(1):32-8. doi: 10.1128/iai.24.1.32-38.1979.
6
Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects.C3H/HeJ小鼠的免疫反应性：丁醇提取的脂多糖（LPS）引发LPS介导效应的差异能力。
J Exp Med. 1978 Mar 1;147(3):800-13. doi: 10.1084/jem.147.3.800.
7
Mild alkaline hydrolysis of lipopolysaccharide endotoxin enhances its mitogencity for murine B cells.脂多糖内毒素的温和碱性水解增强了其对小鼠B细胞的促有丝分裂活性。
Infect Immun. 1977 Jul;17(1):205-14. doi: 10.1128/iai.17.1.205-214.1977.

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Immunization of normal mouse spleen cell suspensions in vitro.体外对正常小鼠脾细胞悬液进行免疫接种。
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Nature and linkages of the fatty acids present in the lipid-A component of Salmonella lipopolysaccharides.沙门氏菌脂多糖脂质A成分中存在的脂肪酸的性质和联系。
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The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis.利用细菌脂多糖来表明抗体合成的诱导需要两个信号。
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The lack of cellular cooperation in the immune response to E. coli 0127.在针对大肠杆菌0127的免疫反应中细胞协作的缺失。
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Maturation of mitogen-activated bone marrow-derived lymphocytes in the absence of proliferation.有丝分裂原激活的骨髓来源淋巴细胞在无增殖情况下的成熟
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8
Stimulation of DNA synthesis in mouse lymphoid cells by polyanions in vitro. I. Target cells and possible mode of action.体外多聚阴离子对小鼠淋巴细胞DNA合成的刺激作用。I. 靶细胞及可能的作用方式。
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9
The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule.脂多糖对源自骨髓的小鼠淋巴细胞的促有丝分裂作用。脂多糖A作为该分子的促有丝分裂部分。
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10
Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides.脂多糖在体外诱导免疫球蛋白和抗体合成
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对细菌脂多糖的促有丝分裂反应和抗原反应的分离。

Separation of the mitogenic and antigenic responses to bacterial lipopolysaccharide.

作者信息

Poe W J, Michael J G

出版信息

Immunology. 1976 Feb;30(2):241-8.

PMID:770315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1444980/
Abstract

An attempt was made to separate the antigenic and mitogenic properties of E. coli bacteria and bacterial lipopolysaccharide antigen inhibited the mitogenic response by the cultures but did not inhibit the induction of anti-LPS antibody or polyclonal antibody synthesis to SRBC. Dextran sulphate, acting as a B-cell mitogen, increased the mitogenic response in spleen cell cultures incubated with bacteria, but did not affect the production of anti-LPS antibody. Mild alkaline hydrolysis (0-1 N NaOH at 56 degrees) of LPS destroyed the mitogenic properties of the molecule, leaving the antigenic properties qualitatively intact. Harsher conditions of base hydrolysis destroyed both the mitogenic and antigenic properties of LPS, as determined by antigenicity in murine spleen cell cultures and haemagglutination inhibition tests.

摘要

曾尝试分离大肠杆菌的抗原性和促有丝分裂特性，细菌脂多糖抗原抑制了培养物的促有丝分裂反应，但未抑制抗脂多糖抗体的诱导或对绵羊红细胞的多克隆抗体合成。作为B细胞促有丝分裂原的硫酸葡聚糖增加了与细菌一起培养的脾细胞培养物中的促有丝分裂反应，但不影响抗脂多糖抗体的产生。脂多糖的温和碱水解（56℃下0-1N氢氧化钠）破坏了分子的促有丝分裂特性，使抗原性在质量上保持完整。通过小鼠脾细胞培养物中的抗原性和血凝抑制试验确定，更苛刻的碱水解条件破坏了脂多糖的促有丝分裂和抗原特性。