Ng T P, Lee H S, Malik M A, Chee C B, Cheong T H, Wang Y T
Department of Community, Occupational and Family Medicine, National University of Singapore.
Occup Med (Lond). 1995 Feb;45(1):45-8. doi: 10.1093/occmed/45.1.45.
Following the identification of an index case of occupational asthma, we assessed the respiratory morbidity in 12 workers exposed to aliphatic polyamines in a chemical factory and in 60 unexposed workers in three other workplaces. Many amine workers reported symptoms of chronic cough (7/12), chronic phlegm (9/12), wheezing (4/12) and exertional breathlessness (3/12). These were significantly more frequent in exposed than in unexposed workers (P < 0.01). They also had significantly greater diurnal variation in peak expiratory flow rates (DV-PEFR) than the unexposed workers (P < 0.01). All four amine workers with wheezing reported onset of symptoms after employment at the factory, and all had DV-PEFR greater than 15%, compared to only one control worker (P < 0.01). A second case of occupational asthma was confirmed by bronchial challenge test. The study indicated a very high risk of asthma and chronic airways disease and a need for stringent measures to protect the health of industrial workers exposed to aliphatic amines in Singapore.
在确认了一例职业性哮喘索引病例后，我们评估了一家化工厂中12名接触脂肪族多胺的工人以及其他三个工作场所60名未接触者的呼吸道发病率。许多接触胺类的工人报告有慢性咳嗽（7/12）、慢性咳痰（9/12）、喘息（4/12）和劳力性气促（3/12）症状。这些症状在接触者中比未接触者更频繁出现（P < 0.01）。他们的呼气峰值流速日变化率（DV-PEFR）也显著高于未接触者（P < 0.01）。所有四名喘息的胺类工人均报告在工厂就业后出现症状，且他们的DV-PEFR均大于15%，相比之下，只有一名对照工人有此情况（P < 0.01）。通过支气管激发试验确诊了第二例职业性哮喘病例。该研究表明，在新加坡，接触脂肪族胺类的产业工人患哮喘和慢性气道疾病的风险非常高，需要采取严格措施来保护他们的健康。
