Ngassa P C, Egbe J A
Clinical Epidemiology Unit (CEU), University of Yaoundé I, Cameroon.
Int J Gynaecol Obstet. 1994 Dec;47(3):241-6. doi: 10.1016/0020-7292(94)90568-1.
To determine the association between maternal genital Chlamydia trachomatis infection in pregnancy and the risk of preterm labor. The hypothesis tested was that a greater proportion of women experiencing preterm labor would have Chlamydia trachomatis than controls who were not experiencing preterm labor.
A case-control study in Yaoundé (Cameroon), involving 126 women of gestational age between 28 and 34 weeks, using serology and cervical swab cultures. Data analysis involved simple comparative descriptive statistics as well as univariate and multivariate analysis.
The odds of experiencing preterm labor and having genital chlamydial infection were 72.59 (exact 95% C.I. 0.99-7.14); O.R.MH (Mantel-Haenszel) 2.80 (approximate 95% C.I. 1.13-6.97) using serological tests. The proportion of women with positive cervical swab cultures was statistically significantly different between cases and controls (Fisher's exact test, P = 0.02).
Routine screening and treatment of pregnant women with Chlamydia trachomatis (along with their partners) may be beneficial in reducing the incidence of preterm labor and delivery and hence the perinatal mortality rate.
确定孕期母体沙眼衣原体感染与早产风险之间的关联。所检验的假设是，与未发生早产的对照组相比，发生早产的女性中沙眼衣原体感染比例更高。
在雅温得（喀麦隆）进行一项病例对照研究，纳入126名孕周在28至34周之间的女性，采用血清学检测和宫颈拭子培养。数据分析包括简单的比较描述性统计以及单变量和多变量分析。
采用血清学检测时，发生早产且有生殖道衣原体感染的比值比为72.59（确切95%可信区间0.99 - 7.14）；采用Mantel-Haenszel法计算的比值比为2.80（近似95%可信区间1.13 - 6.97）。病例组和对照组宫颈拭子培养阳性女性的比例在统计学上有显著差异（Fisher精确检验，P = 0.02）。
对孕妇（及其性伴侣）进行沙眼衣原体的常规筛查和治疗可能有助于降低早产和分娩的发生率，从而降低围产期死亡率。
